Plasma epinephrine disturbances in diabetic subjects during standing and after isometric exercise

The Journal of Clinical Endocrinology and Metabolism
A B Gustafson, R K Kalkhoff

Abstract

Effects of isometric exercise on plasma norepinephrine (NE), epinephrine (E), and related factors (mean +/- SE) were studied in 10 healthy, insulin-dependent diabetic subjects and 10 matched control adults. Measurements were obtained after 30 min of bedrest and sequentially during 10 min of upright posture and 5 min of handgrip and after 15 min of rest while still upright. In control and diabetic groups, respectively, basal plasma NE (180 +/- 22 vs. 169 +/- 27 pg/ml) and E (24 +/- 4 vs. 33 +/- 8 pg/ml) as well as heart rate and mean blood pressure did not differ. However, E responses to standing and recovery from isometric exercise in diabetic subjects significantly exceeded control values 2-fold (P less than 0.05) and were accompanied by exaggerated increases in heart rate (P less than 0.05); whereas NE, mean blood pressure, plasma GH, and glucagon profiles during all periods were not significantly different. Exaggerated E responses in diabetic patients were associated with plasma glucose increments above resting values during grip and recovery of 21 and 41 mg/dl, respectively; slightly though significantly higher plasma cortisol responses, and low, fixed concentrations of plasma insulin. These findings contrasted to correspon...Continue Reading

Citations

Feb 1, 1990·Physiology & Behavior·L L Bellush, W N Henley
Dec 1, 1988·Journal of Endocrinological Investigation·R Giorgino
Jul 1, 1990·Journal of Endocrinological Investigation·G Del RioL Della Casa

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