Plasma, erythrocyte and platelet magnesium levels in type 1 diabetic patients with microalbuminuria and clinical proteinuria

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
A AllegraF Corica

Abstract

We evaluated plasma, erythrocyte and platelet magnesium levels in patients with insulin-dependent diabetes mellitus (IDDM) with normoalbuminuria (N = 10), microalbuminuria (N = 10), and clinical proteinuria (N = 7), and in a group of healthy subjects (N = 10). We found that IDDM patients had lower platelet magnesium levels when compared to controls. Lower platelet magnesium concentrations were found in patients with microalbuminuria (1.859 +/- 0.47 vs 2.340 +/- 0.46 mumol/10(8) cells, p < 0.05) and in those with clinical proteinuria (1.522 +/- 0.19 vs 2.340 +/- 0.46 mumol/10(8) cells, p < 0.01) with respect to the group with normoalbuminuria. In the groups with microalbuminuria and clinical proteinuria we detected a negative correlation between HbA1c and both plasma and platelet magnesium. Our findings indicate that microalbuminuria and clinical proteinuria are associated with an altered magnesium homeostasis. In particular, decreased platelet magnesium concentrations could represent an additional risk factor in the pathogenesis of microvascular complications of diabetes.

References

Sep 1, 1990·Diabetologia·G PaolissoP Lefèbvre
Feb 1, 1989·Diabetes Care·G PaolissoF D'Onofrio
Sep 1, 1985·Annals of Clinical Biochemistry·N B RobertsW H Taylor
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Citations

Jan 8, 2014·Journal of Diabetes·Assimina Galli-TsinopoulouKyriaki Karavanaki
Jul 5, 2008·The British Journal of Nutrition·Maurice J Arnaud
Apr 19, 2018·Journal of Clinical Gastroenterology·Faisal KamalColin W Howden
Jul 13, 2018·Obstetric Medicine·Adam Morton
Dec 5, 2020·Journal of Translational Medicine·Clementina SitziaMassimiliano Marco Corsi Romanelli
Jan 16, 2021·Therapeutic Advances in Endocrinology and Metabolism·Peter R van DijkH J G Bilo

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