PMID: 6970258Feb 1, 1981Paper

Plasma exchange in selected patients with juvenile rheumatoid arthritis

The Journal of Pediatrics
E J BrewerJ D Milam

Abstract

Plasma exchange with either fresh-frozen plasma or 5% albumin solution as replacement fluid was performed in four selected patients with juvenile rheumatoid arthritis unresponsive to standard therapy. One 13-year-old boy with life-threatening systemic disease experienced a partial remission of disease and tolerated a decrease in prednisone dose from 15 to 4 mg daily following 14 exchanges with FFP. A 14-year-old girl, dwarfed by systemic disease and long-term corticosteroid therapy, was able to discontinue prednisone and grew 6.3 cm in 11 months following 18 plasma exchanges with FFP. An 8-year-old girl with pauciarticular disease, antinuclear antibody, and uncontrollable iridocyclitis underwent 16 plasma exchanges with 5% albumin solution as replacement; despite removal of antinuclear antibody, her eye disease and arthritis were not helped. A 16-year-old girl with erosive, polyarticular JRA showed no detectable change in her articular disease following nine exchanges. Transient decreases in hematocrit, complement components, and immunoglobulin concentrations occurred. In three patients Westergren sedimentation rate decreased for up to five months after exchanges. One patient died suddenly during an exchange with FFP; the cause...Continue Reading

References

Mar 8, 1979·The New England Journal of Medicine·C M LockwoodD K Peters
Jul 1, 1979·Arthritis and Rheumatism·D J WallaceJ R Klinenberg
Jul 1, 1974·Annals of the Rheumatic Diseases·D A PersonJ T Sharp
Apr 1, 1980·Arthritis and Rheumatism·E J BrewerE Barkley
Jul 1, 1980·Arthritis and Rheumatism·R S RothwellJ S Percy

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Citations

Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S C JordanR N Fine
Mar 1, 1983·Indian Journal of Pediatrics·A Nanu, S K Sood
Jul 1, 1983·The American Journal of Medicine·M D RubensteinM A Edwards
Nov 6, 1982·Lancet
May 7, 1983·Lancet·D W Huestis
Apr 1, 1982·Archives of Disease in Childhood·E A Robinson
Jul 1, 2004·Transfusion·Jeffrey McCulloughMerlyn Sayers
Dec 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·J H AntonyJ G McLeod
Jan 1, 1984·Vox Sanguinis·E M ZiselmanH A Wurzel
Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·E Patten
Jan 1, 1993·Journal of Clinical Apheresis·D D KiprovB C McLeod
Jun 1, 1984·Disease-a-month : DM·D J Wallace, J R Klinenberg

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