PMID: 48833May 31, 1975Paper

Plasma exchange in the management of homozygous familial hypercholesterolaemia

Lancet
G R ThompsonN B Myant

Abstract

Two young women with homozygous familial hypercholesterolaemia and coronary and aortic atheroma were treated by repeated plasma exchange, using a continuous-flow blood-cell separator, for 4 and 8 months. A pronounced reduction in plasma cholesterol and low-density lipoprotein (L.D.L.) concentrations was achieved by exchanging each patient's plasma with cholesterol-free plasma protein fraction (B.P.), at 3-weekly intervals on an outpatient basis. By pre-labelling the patients' cholesterol with 14-C and comparing the specific activity of the cholesterol in adipose tissue with that in plasma, evidence was obtained of an influx of tissue cholesterol into plasma after each exchange. There was no side-effects and both patients lost their angina. Plasma exchange offers a new and practical approach to the long-term management of this lethal disorder and may also provide information about the possible reversibility of human atheroma.

References

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Citations

Sep 1, 1991·Digestive Diseases and Sciences·T TakahashiY Nosé
Jan 1, 1988·Journal of Inherited Metabolic Disease·G R Thompson
Jan 1, 1984·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A AngelN B Myant
Sep 26, 2012·Clinical Research in Cardiology Supplements·Peter Schuff-WernerPeter Kohlschein
Oct 14, 2006·Current Treatment Options in Cardiovascular Medicine·Patrick M Moriarty
Jul 25, 2009·Current Treatment Options in Cardiovascular Medicine·Puja K MehtaLaurence S Sperling
May 16, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·S MoorjaniJ Awad
Dec 14, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·D GairinJ C Fruchart
Oct 1, 1978·Atherosclerosis·L A SimonsJ C Biggs
Mar 1, 1980·Atherosclerosis·L A SimonsJ C Biggs
Aug 1, 1994·Atherosclerosis·E J SchaeferP W Wilson
Jan 1, 1991·Progress in Lipid Research·E KorenR D Fugate
Feb 1, 1996·Journal of Clinical Anesthesia·C D CollardY Harati
Jun 25, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Eldad J DannLilach Bonstein
Mar 6, 2003·Atherosclerosis·Gilbert R Thompson
Jun 18, 1977·Lancet
Jul 23, 1983·Lancet·K F Michaelsen, K Taudorf
Nov 3, 1996·Transfusion Science·H UllrichG Schmitz
May 11, 2000·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·N Tani
Nov 29, 2001·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·T Bosch
Aug 8, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Sebastian Schulte-EistrupYukihiko Nosé
Mar 1, 1979·The New England Journal of Medicine·M MuggeoC R Kahn
Jun 26, 1980·The New England Journal of Medicine·M E KingR S Lees
Mar 22, 1984·The New England Journal of Medicine·K H Shumak, G A Rock
May 16, 1985·The New England Journal of Medicine·E J Schaefer, R I Levy
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·W Stoffel, T Demant
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael D LewisSarala Malla
Jul 14, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R Leon OchiaiJohn D Clemens
Feb 1, 1979·European Journal of Clinical Investigation·A V Jadhav, G R Thompson

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