Plasma exchange versus intravenous immunoglobulin for myasthenia gravis crisis: an acute hospital cost comparison study.

Journal of Clinical Neuromuscular Disease
Chad HeatwoleKatia Noyes

Abstract

To compare the short-term financial costs of treating a patient in myasthenia gravis crisis with intravenous immunoglobulin (IVIG) versus plasma exchange. An itemized comparative cost-minimization analysis of IVIG versus plasma exchange for myasthenia gravis crisis was performed. Calculations were based on each therapy's implementation cost, associated hospitalization times, and predicted cost to treat known complications. A cost superiority determination was proposed based on the total cost profile of each therapy. The difference in total cost favored IVIG over plasma exchange with an average savings of $22,326 per patient. Sensitivity analysis demonstrated that overall costs are highly dependent on IVIG dosing, hospital lengths of stay, and the number of plasma exchange days required. The use of IVIG for myasthenia gravis crisis may be a short-term cost minimizing therapy compared with plasma exchange. Additional prospective studies are required to evaluate the extended cost profile and efficacy of these therapies.

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Citations

Feb 8, 2014·Current Treatment Options in Neurology·Khalid El-SalemSaid S Dahbour
Oct 25, 2016·Neurologia i neurochirurgia polska·Izabela RozmilowskaHanna Misiolek
Aug 18, 2016·Acta neurologica Belgica·Athena Alipour-FazMaryam Peyvandi
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Oct 17, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Mickael BonnanPhilippe Cabre
Dec 1, 2012·Rinshō shinkeigaku = Clinical neurology·Hidenori Matsuo
Feb 14, 2020·Current Treatment Options in Neurology·Alok PatelStarane A Shepherd
May 20, 2020·The Journal of Critical Care Medicine·Rodica Balasa
May 5, 2020·PharmacoEconomics·Erik LandfeldtHanns Lochmüller
Aug 1, 2020·Frontiers in Neurology·Maria Elena Farrugia, John A Goodfellow
Aug 24, 2016·Journal of Clinical Neuromuscular Disease·Paola Ortiz-SalasJesús H Rodriguez Q
Mar 9, 2021·Journal of Family Medicine and Primary Care·Ashu DograSanjay Prakash
Jan 28, 2015·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Rajesh KumarAmarjit Kaur

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