Plasma exchanges for the treatment of severe systemic necrotizing vasculitides in clinical daily practice: Data from the French Vasculitis Study Group

Journal of Autoimmunity
Gonzalo de LunaFrench Vasculitis Study Group (FVSG)

Abstract

The use of plasma exchanges (PLEX) in systemic necrotizing vasculitides (SNV) still need to be codified. To describe indications, efficacy and safety of PLEX for the treatment of SNV, we conducted a multicenter retrospective study on patients with ANCA-associated vasculitis (AAV) or non-viral polyarteritis nodosa (PAN) treated with PLEX. One hundred and fifty-two patients were included: GPA (n = 87), MPA (n = 56), EGPA (n = 4) and PAN (n = 5). PLEX were used for rapidly progressive glomerulonephritis (RPGN) in 126 cases (86%), alveolar hemorrhage in 64 cases (42%), and severe mononeuritis multiplex in 23 cases (15%). In patients with RPGN, there was a significant improvement in renal function compared to baseline value (P < 0.0001), the plateau being reached at month 3 after PLEX initiation, and estimated glomerular filtration rate improved especially as the number of PLEX increased. In patients with alveolar hemorrhage, mechanical ventilation was discontinued in all patients after a median time of 15 days. Patients treated for mononeuritis multiplex showed improvement of severe motor weakness. After a median follow of 22 months, 18 deaths (12%) were recorded, mainly in patients with RPGN and within the first 6 months. Incidenc...Continue Reading

References

Aug 2, 1979·The New England Journal of Medicine·A S FauciS M Wolff
Dec 1, 1979·The American Journal of Medicine·E S LeibH E Paulus
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Philip J KlemmerRonald J Falk
Jun 10, 2004·Arthritis and Rheumatism·L GuillevinUNKNOWN French Vasculitis Study Group
Jun 22, 2007·Journal of the American Society of Nephrology : JASN·David R W JayneUNKNOWN European Vasculitis Study Group
Jul 22, 2010·The New England Journal of Medicine·Rachel B JonesUNKNOWN European Vasculitis Study Group
Jul 22, 2010·The New England Journal of Medicine·John H StoneUNKNOWN RAVE-ITN Research Group
Aug 3, 2010·Rheumatology·Carole Pierrot-Deseilligny DespujolLoïc Guillevin
Nov 10, 2010·JAMA : the Journal of the American Medical Association·Thomas F HiemstraUNKNOWN European Vasculitis Study Group (EUVAS)
Jan 5, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael WalshDavid Jayne
Sep 11, 2012·Annals of the Rheumatic Diseases·Alfred MahrUNKNOWN French Vasculitis Study Group (FVSG) and the European Vasculitis Society (EUVAS)
Oct 10, 2012·Arthritis and Rheumatism·J C JennetteR A Watts
Apr 22, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Luis F QuintanaDavid Jayne
Nov 6, 2014·The New England Journal of Medicine·Loïc GuillevinUNKNOWN French Vasculitis Study Group

❮ Previous
Next ❯

Citations

Jan 15, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Divi CornecUlrich Specks
Dec 6, 2017·Zeitschrift für Rheumatologie·Jan Henrik SchirmerFrank Moosig
Oct 3, 2018·Expert Review of Gastroenterology & Hepatology·Johan NobleLionel Rostaing
Jun 25, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yoshiyuki AbeNaoto Tamura
Sep 20, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Catherine JosephPoyyapakkam R Srivaths
Dec 14, 2018·Nature Reviews. Rheumatology·Daigo NakazawaAkihiro Ishizu
Apr 30, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Keisuke NishimuraHiroyuki Murabe
Dec 30, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andreas KronbichlerVladimir Tesar
Mar 18, 2021·Zeitschrift für Gastroenterologie·Florian Gunnar ScurtChristos Chatzikyrkou
Nov 12, 2020·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Alexis RégentBenjamin Terrier
Aug 14, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·M Mörtzell HenrikssonB Stegmayr

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.