Plasma exudation in the skin measured by external detection of conversion electrons

European Journal of Nuclear Medicine
A KarambatsakidouP Wollmer

Abstract

A novel technique for measurement of plasma exudation in the skin is described. Transferrin labelled in vivo with indium-113m is used as a plasma tracer. The conversion electrons from 113mIn are detected with a polystyrene crystal mounted on a photomultiplier tube. Owing to the short range of the electrons in tissue, background radiation from tracer circulating in underlying tissue will be very small, allowing plasma exudation in the skin to be detected with a high signal to noise ratio. The characteristics of the detector system are described in model experiments using sheets of mylar to simulate soft tissue. The acute inflammatory response to histamine provocation was studied in guinea pig skin. A dose-related increase in count rate representing vasodilatation and plasma exudation was detected over the skin after histamine provocation. The electron radiation system appears suitable for detection of low levels of superficial radioactivity and for pathophysiological studies of the skin.

References

May 1, 1991·Medical Physics·H B BarberC Ortale Baccash
Jun 1, 1991·The British Journal of Surgery·B R DavidsonP B Boulos
Apr 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·F HosainH N Wagner

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Citations

Nov 5, 2005·Clinical Physiology and Functional Imaging·Vladimir EvilevitchPer Wollmer
Jun 1, 1999·Acta Physiologica Scandinavica·V EvilevitchP Wollmer
Sep 24, 2004·Clinical Physiology and Functional Imaging·Vladimir EvilevitchPer Wollmer

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