Plasma factor XIII activity in patients with disseminated intravascular coagulation.

Yonsei Medical Journal
Jae Woo SongJi-Hyuk Rhee

Abstract

The objective of this study was to investigate the correlation between factor XIII (FXIII) activity and disseminated intravascular coagulation (DIC) parameters and also to evaluate the clinical usefulness of DIC diagnosis. Citrated plasma from eighty patients with potential DIC was analyzed for FXIII activity. The primary patient conditions (48 male and 32 female, mean age, 51 years) were malignancy (n = 29), infection (n = 25), inflammation (n = 6), heart disease (n= 3), thrombosis (n = 2), injury (n = 2), and other miscellaneous conditions (n = 13). FXIII testing was performed using the CoaLinkTM FXIII Incorporation Assay Kit (PeopleBio Inc.). Among 80 patients who were suspected to have DIC based on clinical analysis, 46 (57.5%) fulfilled the overt DIC criteria (DIC score > = 5) according to the International Society of Thrombosis and Haemostasis. FXIII levels in the plasma were significantly decreased in overt DIC compared to non-overt DIC patients (mean 75.1% and 199.7% respectively, p < 0.0001). Interestingly, we found a significant inverse correlation between DIC scores and FXIII activity. In addition, FXIII activity significantly correlated with other hemostatic markers that included platelet count, prothrombin time, ac...Continue Reading

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Citations

Dec 15, 2015·Journal of Gastroenterology·Christoffer SoendergaardOle Haagen Nielsen
Feb 15, 2013·Journal of Thrombosis and Haemostasis : JTH·C SoendergaardO H Nielsen
Nov 15, 2011·The Veterinary Journal·Brigitte DircksReinhard Mischke
Sep 17, 2016·Case Reports in Obstetrics and Gynecology·Michael ChengAndrew A Rosenthal
Mar 21, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hiroki KawanoAkitada Ichinose
Sep 25, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Atsushi YasumotoYutaka Yatomi
Apr 3, 2021·Analytical and Bioanalytical Chemistry·Daishen LuoDamir B Khismatullin
Jul 22, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Felix Carl Fabian SchmittSonja Alesci

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