Plasma fatty acid binding protein 4 is associated with atherogenic dyslipidemia in diabetes.

Journal of Lipid Research
Anna CabréLluís Masana

Abstract

The aim of this study was to evaluate the impact of adipocyte fatty acid binding protein 4 (FABP4) on the lipid profile in type 2 diabetic subjects. Plasma levels of FABP4 and adiponectin and an extensive lipid profile were analyzed in 169 type 2 diabetic subjects and 105 controls. Type 2 diabetic subjects were categorized according the presence of atherogenic dyslipidemia. Univariate statistical analyses, partial correlation tests, and binary logistic regression models were applied. In type 2 diabetic subjects, FABP4 was positively correlated with plasma triglycerides (P = 0.007), apolipoprotein C-III (apoC-III) (P = 0.009), and all the components of triglyceride-rich lipoproteins, including VLDL triglycerides (P = 0.002), VLDL-cholesterol (P = 0.001), and VLDL apoB (P = 0.001). FABP4 was inversely correlated with apoA-I (P = 0.038), HDL-cholesterol (P = 0.002), and HDL apoA-I (P = 0.010) in type 2 diabetic subjects. These correlations are not significantly affected by age, gender, body mass index, adiponectin, insulin, or any pharmacological treatment. The associations are even stronger when the FABP4/adiponectin ratio is considered. None of these associations were observed in controls. High FABP4 and low adiponectin levels a...Continue Reading

References

Jan 1, 1986·Methods in Enzymology·V N Schumaker, D L Puppione
Nov 4, 2000·Biochimica Et Biophysica Acta·D R FlowerC E Sansom
Nov 4, 2000·Biochimica Et Biophysica Acta·S Xu, P Venge
Mar 14, 2002·Current Opinion in Lipidology·Jeffrey B BoordMacRae F Linton
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Erin E Kershaw, Jeffrey S Flier
Jan 18, 2005·American Journal of Physiology. Heart and Circulatory Physiology·David C W LauSubodh Verma
Nov 24, 2005·American Journal of Physiology. Endocrinology and Metabolism·Ann V HertzelDavid A Bernlohr
Aug 22, 2006·European Journal of Clinical Investigation·D Stejskal, M Karpisek

❮ Previous
Next ❯

Citations

May 7, 2013·Cardiovascular Diabetology·Anna CabréLluís Masana
Oct 13, 2011·Lipids in Health and Disease·Hao Wang, Dao-Quan Peng
Apr 15, 2010·Journal of Lipid Research·Anna CabréLluís Masana
Dec 17, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Bang-Gee HsuJi-Hung Wang
Oct 24, 2013·Aging Clinical and Experimental Research·Marco MasettiMarco Zoli
Jan 26, 2016·Metabolic Syndrome and Related Disorders·Harry Robberecht, Nina Hermans
Dec 14, 2011·Revista Española De Cardiología·Iolanda LázaroLluís Masana
Jul 4, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xuejun ShangguanMinyue Dong
Sep 8, 2015·Biochimica Et Biophysica Acta·Paula SaavedraLluís Masana
Jul 5, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·D IbarretxeL Masana
May 25, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Iolanda LázaroLourdes Ibáñez
May 8, 2016·Atherosclerosis·Alba BosquetLluís Masana
Apr 15, 2015·Journal of the Saudi Heart Association·M Al QahtaniH Alshammari
Mar 17, 2012·Atherosclerosis·Anna CabréJordi Salas-Salvadó
Jul 20, 2014·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Paula SaavedraLluís Masana
Feb 7, 2019·Journal of Atherosclerosis and Thrombosis·Masato Furuhashi
Jun 11, 2011·Journal of Hypertension·Sven Haufe, Jens Jordan
Feb 11, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yuan-yuan LiJiang-feng Mao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.