Plasma fatty acid-binding protein 4, nonesterified fatty acids, and incident diabetes in older adults.

Diabetes Care
Luc DjousséKenneth J Mukamal

Abstract

To examine the relation of fatty acid-binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults. We ascertained incident diabetes among 3,740 Cardiovascular Health Study participants (1992-2007) based on the use of hypoglycemic medications, fasting glucose ≥ 126 mg/dL, or nonfasting glucose ≥ 200 mg/dL. FABP4 and NEFA were measured on specimens collected between 1992 and 1993. Mean age of the 3,740 subjects studied was 74.8 years. For each SD increase in log FABP4, hazard ratios (HRs) for diabetes were 1.35 (95% CI 1.10-1.65) for women and 1.45 (1.13-1.85) for men controlling for age, race, education, physical activity, cystatin C, alcohol intake, smoking, self-reported health status, and estrogen use for women (P for sex-FABP4 interaction 0.10). BMI modified the FABP4-diabetes relation (P = 0.009 overall; 0.02 for women and 0.135 for men), in that statistically significant higher risk of diabetes was mainly seen in men with BMI <25 kg/m(2) (HR per SD: 1.78 [95% CI 1.13-2.81]). There was a modest and nonsignificant association of NEFA with diabetes (P(trend) = 0.21). However, when restricted to the first 5 years of follow-up, multivariable-adjusted HRs for diabetes were 1.0 (ref.), 1.68 (95% CI 1...Continue Reading

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Citations

Jan 24, 2014·Cardiology Research and Practice·Luc DjousséNona Sotoodehnia
Aug 19, 2015·Metabolism: Clinical and Experimental·Isha AgarwalKen J Mukamal
Aug 9, 2013·Circulation. Heart Failure·Luc DjousséJoachim H Ix
Feb 2, 2019·Journal of Lipid Research·Kacey J PrenticeGökhan S Hotamisligil
Dec 10, 2019·Current Opinion in Lipidology·Kenneth J Mukamal
Apr 7, 2020·Journal of the American Heart Association·Obiora EgbucheKenneth J Mukamal
Sep 12, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Peter D AhiawodziKenneth J Mukamal
Feb 7, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Carl P WaltherKenneth J Mukamal
Jul 11, 2021·Journal of Clinical Lipidology·Sarah O NomuraMichael Y Tsai

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Methods Mentioned

BETA
ELISA
acylation

Software Mentioned

Stata

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