PMID: 6788970May 1, 1981

Plasma fatty acid patterns of bone marrow transplant patients primarily supported by fat-free parenteral nutrition

JPEN. Journal of Parenteral and Enteral Nutrition
G W ClemansC Cheney

Abstract

Oral food tolerance is compromised by drug and radiation therapy administered to patients undergoing bone marrow transplantation for hematological malignancy or aplastic anemia. Resultant decreases in oral fat intake coincident with fat-free parenteral nutrition may predispose patients to essential fatty acid (EFA) deficiency. Determinations were made of the fatty acid composition of plasma total lipid from 20 bone marrow transplant patients on admission, at the time of bone marrow transplant, and on days 7, 14, 30, and 60 post-bone marrow transplant. Patients ate ad libitum but with little appetite and received fat-free parenteral nutrition interrupted for numerous blood product and drug infusions. Abnormal EFA status was manifest (20:3 omega 9/20:4 ratio greater than 0.2) in 12 of 20 patients during the course of treatment. Plasma EFA status was consistently correlated with oral fat intake but not with sex, age, percentage of ideal body weight, or amount of plasma infused. This suggests that dietary fat was absorbed limiting the severity of EFA deficiency. Interruptions of glucose infusion averaging only about 2 hours/day, also may have helped moderate the deficiency.

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Citations

Jul 4, 2001·JPEN. Journal of Parenteral and Enteral Nutrition·P LenssenG B McDonald
Oct 15, 1984·Cancer·M L HutchinsonN Flournoy
Jul 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J Palmblad, H Gyllenhammar
Jul 24, 2019·JPEN. Journal of Parenteral and Enteral Nutrition·Kathleen H McGrathJason Yap
Sep 20, 2019·Pediatric Blood & Cancer·Kathleen H McGrath

Related Concepts

Hypoplastic Anemia
Ghee
Fat Emulsions, Intravenous
Fatty Acids, Essential
Hematological Disease
Lipids
Malignant Neoplasms
Parenteral Nutrition
Parenteral Nutrition, Total
Bone Marrow Cell Transplantation

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

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