PMID: 589167Nov 19, 1977

Plasma fenfluramine levels, weight loss, and side effects

British Medical Journal
J A InnesD B Campbell

Abstract

Fifty women with refractory obesity received fenfluramine for 20 weeks. Every two weeks details of weight change, drug dose, degree of anorexia, and any side effects were recorded and plasma was obtained for fenfluramine and norfenfluramine measurements. Of the 41 patients available for final analysis 26 achieved a maximum plateau dose of 160 mg/day. Plasma fenfluramine concentrations did not correlate with the degree of anorexia or with the incidence of side effects other than the severity of dream disturbance. There was a highly significant relation between weight loss and plasma fenfluramine and norfenfluramine concentrations and also between weight loss and the presence of sustained anorexia. Women who achieved mean plateau concentrations over 200 ng/ml lost a mean 8.8 kg while those with concentrations less than 100 ng/ml lost a mean of only 2.1 kg. When fenfluramine is prescribed in refractory obesity the dose should be increased stepwise until either satisfactory weight loss is achieved or troublesome side effects appear.

References

Jun 1, 1973·The Journal of Pharmacy and Pharmacology·J E BlundellM B Leshem
Mar 1, 1973·La Vie médicale au Canada français·J P Sedgwick
Sep 10, 1966·British Medical Journal·J F MunroL J Duncan

Citations

Dec 1, 1989·Journal of Autism and Developmental Disorders·G EkmanL Wetterberg
Oct 1, 1985·Pharmacology, Biochemistry, and Behavior·J Carlton, N E Rowland
Jan 1, 1986·Progress in Neurobiology·N E Rowland, J Carlton
Feb 19, 1983·Lancet·J G DouglasJ F Munro
Feb 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·M A Carpenter, H J Bodansky
Jan 1, 1979·Current Medical Research and Opinion·C Vauterin, M Bazot
Jan 1, 1986·Appetite·N E Rowland, J Carlton
Jan 1, 1988·Journal of Child Psychology and Psychiatry, and Allied Disciplines·M Campbell
Oct 3, 2001·The Journal of Thoracic and Cardiovascular Surgery·J A CaccitoloH V Schaff
Jun 1, 1981·The Australian and New Zealand Journal of Psychiatry·F A Whitlock
May 1, 1990·The British Journal of Nutrition·M HorowitzD Shearman
Dec 22, 1999·Endocrine Reviews·G A Bray, F L Greenway
Aug 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·E GoodallT Silverstone
Jul 1, 1996·Clinical Endocrinology·T H SchürmeyerA von zur Mühlen
Jan 1, 1979·Scottish Medical Journal·J G DouglasJ F Munro

Related Concepts

Pondimin
Dexnorfenfluramine
Obesity

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