Plasma fibrinogen level: an independent prognostic factor for disease-free survival and cancer-specific survival in patients with localised renal cell carcinoma

BJU International
Jun ObataMototsugu Oya

Abstract

To investigate the impact of perioperative plasma fibrinogen level as a biomarker of oncological outcome in localised renal cell carcinoma (RCC). We consecutively identified 601 patients with localised RCC who underwent curative surgery at a single institution. Subsequent disease recurrence and cancer-specific survival (CSS) were assessed using the Kaplan-Meier method. To evaluate the independent prognostic impact of plasma fibrinogen level, multivariate analysis was performed for these outcomes. Using the defined threshold level of preoperative plasma fibrinogen of ≥420 mg/dL as elevated, we found 56 patients (9.3%) with an elevated plasma fibrinogen level preoperatively. In Kaplan-Meier analysis, there was a significant difference in disease-free survival and CSS rates between patients with and without preoperative plasma fibrinogen levels of ≥420 mg/dL. Multivariate analysis showed that elevated preoperative plasma fibrinogen level was an independent predictor of subsequent disease recurrence and cancer-specific mortality. In a subgroup analysis of the elevated preoperative plasma fibrinogen level group, postoperative normalisation of plasma fibrinogen level was significantly associated with CSS, showing that patients with n...Continue Reading

References

Oct 1, 1982·The American Journal of Surgical Pathology·S A FuhrmanC Limas
Dec 7, 1994·Journal of the National Cancer Institute·A B Cantor, J J Shuster
Jun 1, 1994·Journal of the National Cancer Institute·D G AltmanM Schumacher
Nov 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amnon ZismanArie S Belldegrun
Jun 17, 2003·Carcinogenesis·Henri H VersteegC Arnold Spek
Sep 13, 2003·Chest·Frederick R RicklesPatricia M Fernandez
Oct 2, 2003·Expert Opinion on Biological Therapy·Carolyn A StatonClaire E Lewis
Sep 27, 2007·Journal of the National Cancer Institute·Olivier TrédanIan F Tannock
Jul 23, 2008·Seminars in Thrombosis and Hemostasis·Joseph S Palumbo
Mar 4, 2009·Journal of Experimental & Clinical Cancer Research : CR·Ilya V TsimafeyeuAnna L Yelizarova
Mar 24, 2012·Cancer Cell·Douglas Hanahan, Lisa M Coussens

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Citations

Jan 26, 2017·Journal of Endourology·Ding PengLi-Qun Zhou
Jul 27, 2018·Journal of Clinical Laboratory Analysis·Fan SunXiao-Zhong Wang
Feb 6, 2017·BioMed Research International·Yuejun TianZhiping Wang

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