PMID: 16537986Mar 16, 2006Paper

Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren

Journal of Epidemiology
Chie FujiiHideaki Toyoshima

Abstract

Plasma fibrinogen level has been recognized as an independent risk factor for atherosclerosis and its thrombotic complications in adults. The present study aimed to clarify the association between plasma fibrinogen levels and cardiovascular risk factors in Japanese children. A total of 294 schoolchildren (145 boys and 149 girls) aged 10-13 years in a town in Nagano Prefecture, Japan, were surveyed in 2000 for body mass index (BMI), plasma fibrinogen, serum C-reactive protein (CRP), serum total cholesterol, serum high-density lipoprotein (HDL) cholesterol, hemoglobin (Hb) A1c, and ratio of serum total cholesterol to serum HDL cholesterol (TCHR). The mean value and standard deviation of plasma fibrinogen level among the schoolchildren was 226.0+/-39.7 mg/dL for boys and 245.3+/-40.9 mg/dL for girls; significantly higher for girls. Among plasma fibrinogen tertiles, serum CRP tended to increase with plasma fibrinogen in both boys and girls. An increasing trend was also found in serum total cholesterol in boys, and in TCHR, HbA1c and BMI in girls. Multiple linear regression analysis revealed significant associations of plasma fibrinogen with serum CRP and HbA1c in both sexes, with TCHR in boys, and with BMI in girls. Plasma fibrinog...Continue Reading

References

Jun 15, 1993·Annals of Internal Medicine·E Ernst, K L Resch
Jun 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H IsoY Komachi
Dec 1, 1996·Plant Molecular Biology·Y WuL Erickson
Jan 1, 1997·Frontiers in Bioscience : a Journal and Virtual Library·C A Feghali, T M Wright
Nov 6, 1998·Stroke; a Journal of Cerebral Circulation·B KristensenT Olsson
Jan 15, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·M ErikssonK Schenck-Gustafsson
May 21, 1999·BMJ : British Medical Journal·R R West
Jun 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·G MarescaG Di Minno
Sep 12, 2000·American Journal of Epidemiology·S SatoY Komachi
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·J P BastardB Hainque
Jan 4, 2001·Stroke; a Journal of Cerebral Circulation·M Di NapoliV Bocola
Jul 6, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·H C GeissP Schwandt
Jul 24, 2001·JAMA : the Journal of the American Medical Association·A D PradhanP M Ridker
Jan 16, 2002·Current Opinion in Lipidology·Jorma S A ViikariOlli Simell
Mar 6, 2002·The American Journal of the Medical Sciences·G S Berenson, UNKNOWN Bogalusa Heart Study Investigators
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Prabhakaran BalagopalNelly Mauras
Jun 18, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Monica AcevedoDennis L Sprecher
Jul 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Johannes Hulthe, Björn Fagerberg
Aug 13, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Mikko J JärvisaloOlli T Raitakari
Jul 10, 2003·Journal of Tropical Pediatrics·Halit CamMeltem Ercan
Nov 8, 2003·Diabetologia·M Fasshauer, R Paschke

❮ Previous
Next ❯

Citations

Jun 15, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Abayomi O AkanjiLukman Thalib
Jan 1, 2012·Obesity Research & Clinical Practice·Chie Fujii, Hisataka Sakakibara
Dec 26, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·T Brooks VaughanElaine Moreland
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Clare van MiertLeanne Jones
Nov 28, 2017·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·César Agostinis-SobrinhoRute Santos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.