Plasma fibronectin concentrations in blood products

Intensive Care Medicine
J PerttiläO Peltola

Abstract

Plasma fibronectin is an important opsonic protein of the mononuclear phagocyte system (MPS). In this study, plasma fibronectin concentrations were measured in stored and fresh whole blood, fresh frozen plasma and AGH cryoprecipitate. Stored whole blood had the lowest concentrations (151 +/- 50 mg/l). The concentrations in fresh whole blood plasma (227 +/- 66 mg/l) and fresh frozen plasma (224 +/- 78 mg/l) were similar but significantly higher than in stored whole blood (p less than 0.05). In contrast, AHG cryoprecipitate had the highest fibronectin concentrations (3249 +/- 502 mg/l) (p less than 0.001). In correcting fibronectin deficiency the best results can thus be expected from an infusion of cryoprecipitate, but fresh whole blood and fresh frozen plasma may also increase depressed fibronectin levels.

References

Feb 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·H HögströmU Haglund
Jun 1, 1985·The Journal of Cell Biology·E G HaymanE Ruoslahti
Jan 1, 1988·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J PerttiläK Irjala
Oct 1, 1988·The Journal of Surgical Research·D W EasterA N Ozkan
May 1, 1987·Critical Care Medicine·F HesselvikG Liedén
Aug 1, 1987·Journal of Applied Physiology·L F CohlerW E Charash
Dec 1, 1987·Critical Care Medicine·J F Hesselvik
Jul 1, 1986·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·F LabrousseN T Le Quang
Apr 1, 1986·The Journal of Trauma·F B RogersJ A Barrett
Feb 1, 1983·Journal of Clinical Pathology·M Bowen, T Müller
Jan 1, 1984·Transfusion·E L SnyderD F Mosher
Feb 1, 1983·Annals of Surgery·W O RichardsW Reed
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E OhE Ruoslahti

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Citations

Oct 22, 2002·Journal of the American Veterinary Medical Association·Simon T Kudnig, Khursheed Mama
Feb 22, 2011·Biologicals : Journal of the International Association of Biological Standardization·T V AnilkumarLissy K Krishnan
Nov 25, 1997·Annals of the New York Academy of Sciences·A C Scallet, X Ye

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