May 24, 2012

Plasma fluorescent oxidation products and short-term occupational particulate exposures

American Journal of Industrial Medicine
Jaime E HartEric Garshick

Abstract

Evidence suggests that fine particulate air pollution results in oxidative induced tissue damage. A global fluorescent oxidation products (FLOx) assay (fluorescent intensity (FI) units per milliliter of plasma) was measured in blood samples collected from 236 nonsmoking, Caucasian, male trucking industry workers either prior to, during, or after their work shifts. Occupational exposures to particulate matter (PM)(2.5) were based on job-specific area-level sampling. Generalized linear models were used to determine associations between FLOx levels and PM(2.5) , adjusted for age, time since last meal, alcohol consumption, aspirin, and cholesterol medications. The mean (standard deviation) level of FLOx was 265.9 FI/ml (96.0). Levels of FLOx were higher among older individuals and lower among those who had consumed alcohol in the past 24 hr. However, no associations were observed between FLOx and PM(2.5) . Our results indicate no association between occupational PM(2.5) exposure and this marker of global oxidative stress.

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Citations

Mentioned in this Paper

Engine Exhaust
Log-Linear Models
Air Pollutants, Occupational
Oxidative Stress
Oxidative Stress Analysis
Oxidation
Fluorescent stain
Occupational Exposure
Assay
Viral Markers

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