PMID: 7031209Dec 1, 1981Paper

Plasma free insulin concentrations: keystone to effective management of diabetes mellitus in children

The Journal of Pediatrics
J I Malone, A W Root

Abstract

In patients with insulin-dependent diabetes, the therapeutic effect of prescribed insulin is routinely judged by the response of the blood glucose concentration. Measurement of both free and bound circulating insulin indicates that neither total nor free insulin concentrations correlate with the prescribed insulin dose. Errors of insulin administration may account for this discrepancy. Free insulin rather than total insulin values determine the plasma glucose concentration and the degree of long-term glycemic control as reflected by levels of hemoglobin A1C. Diabetic ketosis and ketoacidosis are strongly associated with absence of free-circulating insulin. Knowledge of plasma-free insulin values is useful in the management of insulin-dependent diabetes mellitus.

References

Mar 1, 1979·Diabetologia·R W Stout
Oct 1, 1976·Diabetes·J I Malone, A W Root

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Citations

Jan 1, 1985·Diabetologia·K FalholtL G Heding
Apr 2, 1984·Klinische Wochenschrift·E A ChantelauM Berger
Nov 29, 2005·Reviews in Endocrine & Metabolic Disorders·Arlan L Rosenbloom
Dec 1, 2011·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Arlan L Rosenbloom
Jan 4, 1993·Journal of Immunological Methods·M J StorchL Kerp
Jan 15, 1996·Molecular and Cellular Endocrinology·S AydinA T Ozçelikay
Sep 1, 1996·Journal of Diabetes and Its Complications·Y OztürkN Yildizoğlu-Ari
Dec 1, 1994·Acta Paediatrica Japonica; Overseas Edition·Y IshidaK Konishi
Jan 23, 2004·Archives of Disease in Childhood·D B DungerUNKNOWN LWPES
May 1, 1983·The Journal of Pediatrics·W P Coleman
May 1, 1996·Clinical Pediatrics·A L Rosenbloom, R Hanas
Mar 8, 2007·Pediatric Diabetes·Joseph WolfsdorfUNKNOWN International Society for Pediatric and Adolescent Diabetes
Feb 24, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Arlan L Rosenbloom

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