Plasma free N-terminal fibronectin 30-kDa domain as a marker of endothelial dysfunction in type 1 diabetes mellitus

European Journal of Clinical Investigation
J SkrhaH Hörmann

Abstract

The plasma free N-terminal fibronectin 30-kDa domain was measured in 44 type 1 diabetic patients and in 20 healthy subjects. A significantly raised mean concentration of a free N-terminal fibronectin 30-kDa domain was found in plasma of diabetic patients with proliferative retinopathy as compared with healthy persons (P less than 0.001). A positive correlation was observed between free N-terminal fibronectin 30-kDa domain and von Willebrand factor in plasma of all examined subjects (r = 0.62, P less than 0.01). A similar correlation was present between 30-kDa domain and albuminuria (r = 0.56, P less than 0.01). However, no relationship was found between fibronectin 30-kDa domain and control of diabetes as assessed by fructosamine concentration. The free N-terminal fibronectin 30-kDa domain may be used as a marker of actual endothelial cell dysfunction in diabetes.

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Citations

Nov 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·J SkrhaP Stolba
Sep 1, 1992·Archives of Biochemistry and Biophysics·R S ZafarD A Walz
Jul 31, 2003·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Reinhard KlingelErnst Küstner
Feb 13, 2001·Endocrine Reviews·J Calles-Escandon, M Cipolla
Apr 2, 2002·Journal of Cardiac Surgery·R E Michler, J M Chen

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