Plasma gamma-glutamyl transpeptidase in heroin addicts

Clinica Chimica Acta; International Journal of Clinical Chemistry
J P Colombo, J Colombo

Abstract

Plasma gamma-glutamyl transpeptidase was measured in 25 heroin addicts. The purpose was to find out if the long term administration of heroin would lead to a stimulation of GGTP due to the detoxication of this drug in the endoplasmatic reticulum of the liver. In 10 patients the elevation of GGTP could be attributed to liver damage, since other liver enzymes were also increased. 15 patients had normal GGTP activities, in 4 of them accompanied by minor elevations of single other hepatic enzymes. In 11 patients the GGTP activity as weel as that of the other enzymes was normal despite heavy chronic herioin abuse. It is therefore improbable that GGTP can be used to diagnose abuse of this drug and to evaluate the progress of drug detoxication treatments and drug abstention as has been proposed in chronic alcoholism.

References

Jun 3, 2009·The American Journal of Medicine·Henri RoukozDeepak L Bhatt
Sep 24, 2004·Basic & Clinical Pharmacology & Toxicology·Yun-Tao ZhangRong-Liang Zheng
Jul 9, 2016·Consciousness and Cognition·Madeleine RansomChristopher Mole
Jan 1, 1996·Addiction Biology·D Banerjee, N K Sarkar
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Citations

Feb 1, 1975·The Journal of Pediatrics·H BartelsI Vogel
Aug 14, 1971·Lancet·G A MoroniS Del Prete
Apr 12, 1974·Deutsche medizinische Wochenschrift·H SchlebuschM Knedel

Related Concepts

Enzymes, antithrombotic
Heroin
Gamma-glutamyl transferase
Hepatic
Gamma Glutamyl Transferase Measurement
Liver Damage
Hepatitis, Alcoholic
Teens
Enzymes for Treatment of Wounds and Ulcers
Addict

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