Plasma ghrelin and obestatin levels are increased in spontaneously hypertensive rats

Peptides
Zhao-Feng LiXing Zheng

Abstract

Obestatin, encoded by the same gene as ghrelin, was first described as a physiological opponent of ghrelin. We investigated fasting plasma ghrelin and obestatin levels in spontaneously hypertensive rats and Wistar-Kyoto rats. We found that ghrelin levels, obestatin levels and the ratio of ghrelin to obestatin were significantly higher in spontaneously hypertensive rats than Wistar-Kyoto rats. Systolic blood pressure and diastolic blood pressure were positively correlated; however, heart period and baroreflex sensitivity were negatively correlated with ghrelin levels. Systolic blood pressure was positively correlated, whereas baroreflex sensitivity was negatively correlated with obestatin levels. In addition, systolic blood pressure was a significantly independent variable of ghrelin levels, obestatin levels, and the ghrelin to obestatin ratio in a multiple regression analysis. Our data suggests that there is a disturbance of ghrelin and obestatin in the circulation of spontaneously hypertensive rats and the ghrelin/obestatin system might play a role in blood pressure regulation.

References

Mar 19, 2002·Hypertension·Yasuo MakinoTatsuhiko Kawarabayashi
Nov 2, 2002·Hypertension·Kiyoshi MatsumuraMitsuo Iida
Jan 28, 2003·Journal of Cardiovascular Pharmacology·He-Hui XieDing-Feng Su
Feb 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Zhi-Fu GuoZheng Zhang
Apr 21, 2007·Stroke; a Journal of Cerebral Circulation·Ai-Jun LiuDing-Feng Su
Sep 6, 2007·American Journal of Physiology. Endocrinology and Metabolism·Marietta Anderwald-StadlerChristian Anderwald
Apr 9, 2008·Peptides·João-Bruno Soares, Adelino F Leite-Moreira

❮ Previous
Next ❯

Citations

Mar 23, 2011·Endocrine·Jiang-Bo LiAkio Inui
Oct 17, 2012·Cardiovascular Diabetology·Manuela AragnoGiampiero Muccioli
Oct 9, 2013·BioMed Research International·Ilia BeberashviliZhan Averbukh
Dec 18, 2013·Peptides·Xue-Jia SuZhao-Feng Li
Apr 5, 2011·Molecular and Cellular Endocrinology·Inge SeimLisa Chopin
Sep 6, 2015·New Biotechnology·Angela SunHelena Nevalainen
Nov 26, 2015·Pregnancy Hypertension·Weiguang WuYingchun Wang
Mar 27, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Naokazu HamadaHiroharu Mifune
Jul 27, 2017·Journal of Cellular and Molecular Medicine·Claudia PennaRiccarda Granata
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·Christina MaierAnton Luger
Apr 12, 2011·Experimental Biology and Medicine·Riccarda GranataEzio Ghigo
Jan 1, 2014·Terapevticheskiĭ arkhiv·I V Tereshchenko, P E Kaiushev
Dec 24, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.