Plasma ghrelin levels are normal in obese patients with idiopathic intracranial hypertension (pseudotumor cerebri)

American Journal of Ophthalmology
Prem S SubramanianNeil R Miller

Abstract

Idiopathic intracranial hypertension (IIH) occurs predominantly in young, obese women. Weight loss may alleviate symptoms of IIH yet may be difficult to achieve. Ghrelin, a gastric hormone, is involved in normal body weight and appetite regulation. Its levels are elevated in syndromes of overeating and decline in simple obesity. We postulated that fasting plasma ghrelin levels are elevated in IIH patients and that the typical postprandial decline in plasma ghrelin may not occur. Prospective, observational case-control study. Prospective study. University hospital and clinic. Sixty-five patients with a diagnosis of IIH and 25 obese control patients (screened for IIH symptoms). Patients with intracranial abnormalities or a history of gastric surgery were excluded. Fasting plasma ghrelin, leptin, and insulin levels were assessed between 8 am and 10 am. Subjects were fed a standard breakfast, and postprandial ghrelin levels were measured 30 minutes later. Fasting plasma ghrelin levels negatively correlated with body mass index in both IIH subjects (r = -.48) and controls; leptin showed a positive correlation with body mass index in both IIH (r =.59) and controls. Levels were not significantly different between the groups. Postprand...Continue Reading

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Citations

Jun 18, 2011·AJNR. American Journal of Neuroradiology·A J Degnan, L M Levy
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Aug 5, 2008·Journal of Neuroimmunology·Alexandra J SinclairSaaeha Rauz
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