PMID: 1205023Dec 1, 1975Paper

Plasma glucagon levels in normal women during pregnancy

Diabetologia
A S LuyckxP J Lefebvre

Abstract

Increased plasma pancreatic glucagon concentrations have been reported during various states of decreased glucose tolerance. In vitro studies have demonstrated that human somatomammotropin stimulates glucagon release. The present investigation aimed at evaluating the role of plasma flucagon in the insulin resistance associated with normal pregnancy. Postprandial samples of plasma were obtained from 156 pregnant women between the 5th and the 40th week of pregnancy and were assayed for blood glucose, plasma insulin, glucagon and free fatty acids. Plasma insulin showed a gradual increase during pregnancy, and reached its maximal values during the last trimester. A moderate but significant increase in plasma glucagon was present between the 16th and the 28th week of gestation, whereas during the first and the last trimester of pregnancy its concentration was similar to that in non pregnant women. Intravenous glucose tolerance was performed during the last trimester and in a group of non pregnant control women. The slight decrease in glucose tolerance and the marked hyperinsulinemia associated with late pregnancy were accompanied by a more rapid and more pronounced decrease in plasma glucagon. A rapid and sustained decrease in gluca...Continue Reading

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Citations

Jun 1, 1979·Diabetologia·P J Lefebvre, A S Luyckx
Oct 1, 1979·Acta diabetologica latina·F FalluccaA Pachì
Nov 1, 1991·Journal of Endocrinological Investigation·I PivaG Federspil
May 16, 2014·Diabetologia·Teresa Mezza, Rohit N Kulkarni
Sep 1, 1986·Canadian Anaesthetists' Society Journal·H S MoseleyA Krishnan
Feb 17, 1998·The British Journal of Psychiatry : the Journal of Mental Science·I F Brockington
Apr 25, 2020·EMBO Reports·Yiping YuYing-Pu Sun

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