Plasma glucose-lowering action of Hon-Chi in streptozotocin-induced diabetic rats

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
J-C ChangJ-T Cheng

Abstract

Hon-Chi was used for anti-hyperglycemic activity screening in streptozotocin-induced diabetic rats (STZ-diabetic rats) in an attempt to develop new substances for handling diabetes. Mandarin Hon-Chi is red yeast rice fermented with Monascus pilous and Monascus purpureus. Single oral administration of Hon-Chi decreased plasma glucose in STZ-diabetic rats in a dose-dependent manner from 50 mg/kg to 350 mg/kg. Similar treatment with Hon-Chi also lowered the plasma glucose in normal rats as effectively as that produced in STZ-diabetic rats. In addition, oral administration of Hon-Chi at the highest dose (350 mg/kg) attenuated the elevation of plasma glucose induced by an intravenous glucose challenge test in normal rats. Moreover, mRNA levels of phosphoenolpyruvate carboxykinase (PEPCK) in liver from STZ-diabetic rats were reversed in a dose-dependent manner by the repeated oral treatment of Hon-Chi three times daily for two weeks. Otherwise, hyperphagia in STZ-diabetic rats was markedly reversed by similar repeated treatment of Hon-Chi. The obtained results suggest that oral administration of Hon-Chi could decrease hepatic gluconeogenesis to lower plasma glucose in diabetic rats lacking insulin.

Citations

Nov 17, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wenxian Wang, Chi-Wai Wong
Nov 27, 2007·Applied Microbiology and Biotechnology·Yii-Lih LinNan-Wei Su
Mar 3, 2012·Applied Microbiology and Biotechnology·Yeu-Ching Shi, Tzu-Ming Pan
Sep 17, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·W-P ChenT-M Pan
Nov 8, 2012·Complementary Therapies in Medicine·Clinton W Yang, Shaker A Mousa
May 22, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Lin-Yu WangJuei-Tang Cheng
Aug 29, 2020·Journal of Agricultural and Food Chemistry·Ju HuQinwan Huang
Sep 28, 2021·Journal of Applied Microbiology·Vishu ChaudharyHarsh Panwar
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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