Plasma glutamate decarboxylase activity in neuropsychiatry

Psychiatry Research
H KaiyaS Nakamura


Plasma glutamate decarboxylase (GAD) activity was measured in patients with endogenous psychoses and neurologic diseases. Unmedicated schizophrenic patients showed no difference in plasma GAD levels compared to controls. Administration of neuroleptics together with anticholinergic agents increased plasma GAD activity in schizophrenic patients. Compared to controls, patients with major depression and bipolar illness showed significantly lower GAD activity. No effect of antidepressants and minor tranquilizers on plasma GAD activity was found. Relatively lower GAD activity was shown in neurotic patients. The enzyme activity in plasma of patients with Huntington's chorea (HC) was lower than control levels. The plasma GAD concentrations correlated with cerebrospinal fluid concentrations in five HC patients.


Aug 1, 1979·Archives of General Psychiatry·J P BennettS H Snyder
Mar 10, 1979·Lancet·A J CrossF Owen
Jul 15, 1975·Life Sciences·E CostaA Suria
Nov 3, 1977·Nursing Mirror·S Powter
Jun 1, 1978·The American Journal of Psychiatry·C A TammingaT N Chase
Feb 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·D LichtshteinR H Belmaker
Feb 1, 1977·The American Journal of Psychiatry·D P Van Kammen
Apr 1, 1975·Journal of Neurochemistry·P MacDonnell, O Greengard
Jan 1, 1974·Psychopharmacologia·J StevensW Foote
Dec 1, 1974·Journal of Neurochemistry·R J Drummond, A T Phillips
Feb 15, 1973·The New England Journal of Medicine·T L PerryM Kloster
Dec 1, 1980·Journal of the Neurological Sciences·E G SpokesL L Iversen
Jan 1, 1980·Archiv für Psychiatrie und Nervenkrankheiten·H M EmrichA Windorfer
Aug 1, 1981·The American Journal of Psychiatry·R H Gerner, T A Hare
Mar 1, 1980·The American Journal of Psychiatry·B I GoldD W Sweeney


Feb 18, 1986·European Journal of Pharmacology·F BorsiniA Meli
Feb 1, 1988·Pharmacology, Biochemistry, and Behavior·F BorsiniA Meli
Oct 13, 1998·Life Sciences·I S Shiah, L N Yatham
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·R T KhistiS P Jain
May 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Beata KarolewiczGregory A Ordway
May 19, 2012·Case Reports in Pediatrics·P RaychaudhuriRajendra Kumar
Jul 31, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Erol Başar
Oct 31, 2002·Human Psychopharmacology·Brendan Belsham
Dec 20, 2003·Annals of the New York Academy of Sciences·Gerard SanacoraJohn H Krystal
Feb 21, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Paul G UnschuldElisabeth B Binder
Jul 31, 2003·Molecular Psychiatry·P BrambillaJ C Soares

Related Concepts

Manic Disorder
Glutamate Decarboxylase
Akinetic-Rigid Variant of Huntington Disease
Neurotic Disorders
Mood Disorders
Organic Mental Disorders, Psychotic

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