PMID: 9535252Apr 16, 1998Paper

Plasma glutathione concentrations in children infected with human immunodeficiency virus

The Pediatric Infectious Disease Journal
J F RodriguezC Díaz

Abstract

Glutathione (GSH) is the principal intracellular defense against oxidants, and HIV-infected individuals tend to have subnormal concentrations in plasma. This GSH deficiency may contribute to the pathogenesis of disease progression. In the pediatric population correlations between GSH concentrations with clinical, immunologic and virologic disease profiles are scarce. The main objectives of this study were (1) to compare plasma GSH concentrations of HIV-infected children and healthy controls and (2) to correlate GSH values with clinical, immunologic and virologic disease indices. Twenty-four HIV-infected and 24 healthy control children entered the study. Plasma concentrations of total glutathione and related thiols were determined. The difference in mean plasma GSH concentrations between HIV-infected (2.96 +/- 0.31 microM) and control (6.62 +/- 0.58 microM) groups was highly significant (P < 0.0001). Linear regression analyses in HIV-infected patients revealed significant correlations between GSH and both absolute CD4+ cell counts (r = 0.56, P = 0.004) and viral load measured as log HIV-RNA PCR (r = -0.49, P = 0.018). GSH concentrations did not significantly correlate with CDC clinical stage but were lower in HIV-infected patien...Continue Reading

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Citations

Sep 29, 2006·Amino Acids·R Van Brummelen, D du Toit
Oct 13, 2000·European Journal of Clinical Investigation·F Staal
Jun 25, 2010·The Journal of Biological Chemistry·Rebecca Pastrana-MenaAdelfa E Serrano
Feb 21, 2009·PLoS Pathogens·Joel Vega-RodríguezAdelfa E Serrano
Jan 14, 2012·Clinical & Developmental Immunology·Shalini DuggalAshish Kumar Duggal
Dec 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·S M Arpadi

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