Plasma granzyme B as a predicting factor of coronary artery disease--clinical significance in patients with chronic renal failure

Journal of cardiology
Tomokazu IkemotoKazuyuki Shimada

Abstract

To elucidate the role of granzyme B in coronary artery disease (CAD) in patients with chronic kidney disease (CKD). We hypothesized that granzyme B plays an important role in the formation of coronary artery lesions in patients with CKD. We studied 141 patients (116 men and 25 women; mean age, 64.2±9.6 years) and 16 control subjects. Diagnosis of CAD was confirmed by selective coronary angiography. CKD was defined as a sustained decrease in the estimated glomerular filtration (eGFR) rate less than 60 mL/min/1.73 m(2) over 3 months. We assigned patients to three groups: CAD without CKD (CAD group, n=46), CKD without CAD (CKD group, n=18), and CAD with CKD (CAD/CKD group, n=77). Plasma granzyme B was measured by enzyme-linked immunosorbent assay. Factors contributing to the severity of CAD were analyzed by multiple regression analysis in patients with CAD. Plasma levels of high-sensitivity CRP (hs-CRP) and granzyme B in the CAD/CKD group were significantly higher than in other groups. A significant positive correlation was observed between plasma hs-CRP and granzyme B levels. A significant negative correlation was observed between eGFR and granzyme B levels. Multiple regression analysis revealed that granzyme B and hs-CRP levels ...Continue Reading

References

Nov 21, 2000·The Journal of Experimental Medicine·J A HeibeinR C Bleackley
Aug 6, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Toshio OhkumaHiroshige Ohashi
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Dominic S C RajPhilip G Zager
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jonathan C ChoyDavid J Granville
Oct 14, 2005·Kidney International·Dominic S C RajPope Moseley
Dec 20, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Judi NairnPaul Henning
Mar 30, 2006·Transplantation·Eric L R BédardRobert Zhong
Nov 9, 2007·American Journal of Nephrology·Fan Yi, Pin-Lan Li
Apr 9, 2008·Current Vascular Pharmacology·Georgios EfstratiadisApostolos Hatzitolios

❮ Previous
Next ❯

Citations

Nov 8, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hala O El MesallamyAshraf I Amin
Jun 5, 2012·Journal of cardiology·Tomoyuki KawadaHirofumi Inagaki
Dec 21, 2010·Journal of cardiology·Yuji SaitoYukihiro Hojo
May 11, 2019·Journal of Endocrinological Investigation·I BarchettaM G Cavallo
Oct 10, 2020·Cellular Signalling·Matthew R Zeglinski, David J Granville

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Caspases in Metabolic Diseases

Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.