PMID: 1911135Jul 1, 1991Paper

Plasma growth hormone-binding activity is low in uraemic children

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
M C Postel-VinayO Mehls

Abstract

Plasma growth hormone-binding protein (GH-BP) activity was evaluated in two groups of prepubertal children with chronic renal failure (CRF) who had been treated with recombinant human GH (rhGH). Group 1 consisted of eight children (mean chronological age 10.8 years) with advanced renal failure; group 2 consisted of nine children (mean chronological age 6 years) presenting with end-stage renal disease, who were on dialysis. Before treatment the specific binding of (125I)hGH to high-affinity GH-BP was low in the two groups (group 1, 17.3 +/- 1.6% of radioactivity; group 2, 14.2 +/- 1.4%) compared with the mean value obtained in normal prepubertal children (24.8 +/- 1.7%). No significant changes in GH-BP activity were found during the 1st year of GH therapy, although growth velocity and plasma levels of insulin-like growth factor-I increased significantly in both groups. The low GH-binding activity found in children with CRF supports the state of GH resistance. The reason for the absence of a GH-BP response to GH therapy has to be clarified.

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Citations

Feb 5, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ralph RabkinFranz Schaefer
Feb 5, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Burkhard TönshoffSonia Ciarmatori
Aug 7, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shefali Mahesh, Frederick Kaskel
Dec 25, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Richard N Fine
Dec 1, 1994·Molecular and Cellular Endocrinology·S M VillaresM C Postel-Vinay
Jul 1, 1992·Baillière's Clinical Endocrinology and Metabolism·O MehlsK Schärer
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Sep 1, 1995·Kidney International·I B Salusky, W G Goodman
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