PMID: 2492135Jan 1, 1989Paper

Plasma growth hormone profile in acromegaly before and ten days after transsphenoidal surgery

Acta Endocrinologica
S EdénS Rosberg

Abstract

Profiles of plasma GH, plasma somatomedin-C and serum PRL concentrations as well as serum GH response to iv TRH were determined in 11 patients with acromegaly before and 10 days after surgery. Blood for profile determinations was drawn from a peripheral vein with a continuous withdrawal pump changing the recipient tube at 30-min intervals. Before surgery all patients had high plasma GH concentrations with irregular peaks and somatomedin-C concentrations were elevated. The response to TRH was abnormal in 8 patients. Three patients had slightly elevated PRL concentrations and one had high PRL concentration (6900 mU/l). Ten days after surgery GH concentrations were still high in 2 patients (greater than 5 mU/l), as were somatomedin-C concentrations (3.2 and 2.4 U/l, respectively). In 3 patients basal GH concentrations were less than 5 mU/l and somatomedin-C concentrations were normal, but there were no major peaks in plasma GH concentrations. In 2 patients major peaks in GH concentrations appeared after surgery, but basal GH concentrations were 1.9 and 0.95 mU/l, respectively. One patient with hyperprolactinemia still had slightly elevated PRL concentration (486 mU/l), but the response to TRH was normalized. Finally, in 4 patients...Continue Reading

Citations

Nov 1, 1994·Clinical Endocrinology·J OscarssonB A Bengtsson
Feb 1, 1990·Clinical Endocrinology·M D LittleyM L Sutton
Oct 1, 1989·Clinical Endocrinology·B A BengtssonG Lindstedt
Aug 1, 1990·Clinical Endocrinology·F RoelfsemaM Frölich
Mar 1, 1994·Clinical Endocrinology·K CaidahlB A Bengtsson

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