PMID: 2512036Mar 1, 1989Paper

Plasma growth hormone profiles and sleep: a study of 13 treated acromegalics

Clinical Endocrinology
H de BoerA P van Seters

Abstract

The plasma growth hormone profiles and sleep patterns of 13 treated male acromegalic patients, aged 29-67 years, were studied. All patients had undergone selective pituitary transsphenoidal surgery 4-9 years previously; five patients had also undergone supplemental pituitary irradiation. Blood samples were taken at 20-min intervals; the sleep patterns were obtained by EEG. GH reserve was assessed after insulin-induced hypoglycaemia and GHRH (1-44) with and without pyridostigmine. The profiles were analysed with the aid of the Pulsar program. Seven out of eight non-irradiated patients had 1-3 nocturnal GH peaks; in the irradiated group only one patient had a normal profile. The GH reserve after insulin-induced hypoglycaemia was normal in seven out of eight non-irradiated patients, and subnormal in all five irradiated patients. In the latter group the GH reserve was diminished when tested with GHRH. One patient from each group had a severe apnoea syndrome; in both cases there was no nocturnal GH increase. The percentage sleep stage 1 was lower for irradiated patients when compared with non-irradiated patients, but the 14 other sleep parameters did not differ. From this study we conclude that the physiological regulation of GH sec...Continue Reading

References

Jan 1, 1987·Biological cybernetics·B KempJ M Franzen
Dec 1, 1987·Clinical Endocrinology·T PekkarinenM Iivanainen
Feb 1, 1987·Clinical Endocrinology·F RoelfsemaH Van Dulken
Mar 1, 1985·The Journal of Clinical Endocrinology and Metabolism·J MendlewiczE Van Cauter
Jun 1, 1972·The Journal of Clinical Endocrinology and Metabolism·H E CarlsonF Snyder
Sep 1, 1968·The Journal of Clinical Investigation·Y TakahashiW H Daughaday
Sep 1, 1983·Journal of Gerontology·P N PrinzI Karacan
Feb 1, 1980·The Journal of Clinical Endocrinology and Metabolism·P JaquetJ Bert

❮ Previous
Next ❯

Citations

Apr 13, 1991·Lancet
Nov 20, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Flavia Lucia ConceiçãoJens Sandahl Christiansen
Nov 1, 1989·Journal of Endocrinological Investigation·F RoelfsemaM Frölich
Oct 1, 1989·Clinical Endocrinology·F RoelfsemaH de Boer
Aug 1, 1990·Clinical Endocrinology·H LuntT J Wilkin
Aug 1, 1990·Clinical Endocrinology·F RoelfsemaM Frölich
Jun 1, 1997·Clinical Pediatrics·J M GerardC Weber
Apr 1, 1991·Perception & Psychophysics·J M Cortese, G J Andersen
Oct 6, 2000·Journal of Endocrinological Investigation·V WeissT Haas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.