Plasma Heme Oxygenase-1 Levels in Patients with Coronary and Peripheral Artery Diseases

Disease Markers
Yoshimi KishimotoYukihiko Momiyama

Abstract

Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate CO, biliverdin, and iron. Since these products have antiatherogenic properties, HO-1 may play a protective role against the progression of atherosclerosis. However, plasma HO-1 levels in patients with atherosclerotic diseases, such as coronary artery disease (CAD) and peripheral artery disease (PAD), have not been clarified yet. We investigated plasma HO-1 levels by ELISA in 410 consecutive patients undergoing elective coronary angiography who also had an ankle-brachial index (ABI) test for PAD screening. Of the 410 study patients, CAD was present in 225 patients (55%) (1-vessel (1-VD), n = 91; 2-vessel (2-VD), n = 66; 3-vessel disease (3-VD), n = 68). PAD (ABI < 0.9) was found in 36 (9%) patients. Plasma HO-1 levels did not differ between 225 patients with CAD and 185 without CAD (median 0.44 versus 0.35 ng/mL), but they were significantly lower in 36 patients with PAD than in 374 without PAD (0.27 versus 0.41 ng/mL, P < 0.02). After excluding the 36 patients with PAD, HO-1 levels were significantly higher in 192 patients with CAD than in 182 without CAD (0.45 versus 0.35 ng/mL, P < 0.05). HO-1 levels in 4 groups of CAD(-), 1-VD...Continue Reading

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Citations

Jun 25, 2020·International Journal of Molecular Sciences·Salvatore Santo SignorelliDomenico Di Raimondo
Jul 28, 2019·International Journal of Molecular Sciences·Yoshimi KishimotoYukihiko Momiyama
Mar 2, 2021·Frontiers in Aging Neuroscience·Wenhua SunDongsheng Li
Jul 3, 2021·Antioxidants·Jirina KaufmanovaJan Evangelista Dyr
Sep 4, 2020·Journal of Neurochemistry·Marisa CressattiHyman M Schipper
Oct 9, 2021·Journal of the American Heart Association·Anja HofmannChristian Reeps

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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