PMID: 46338Jan 4, 1975

Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease

G J Miller, N E Miller


The body cholesterol pool increases with decreasing plasma-high-density-lipoprotein (H.D.L.) but is unrelated to the plasma concentrations of total cholesterol and other lipoproteins. This finding supports existing evidence that H.D.L. facilitates the uptake of cholesterol from peripheral tissues and its transport to the liver for catabolism and excretion. Plasma-H.D.L., is reduced in several conditions associated with an increased risk of future ischaemic heart-disease (I.H.D.), namely hypercholesterolaemia, hypertriglyceridaimia, male sex, obesity, and diabetes mellitus, while subjects with existing clinical I.H.D. have lower levels of H.D.L. than healthy subjects within the same community. It is proposed that a reduction of plasma-H.D.L. concentration may accelerate the development of atherosclerosis, and hence I.H.D., by impairing the clearance of cholesterol from the arterial wall.


Nov 11, 2009·Archives of Neurology·Joshua Z WilleyMitchell S V Elkind
Aug 1, 1990·Clinical Cardiology·R F Leighton
Feb 1, 1991·Clinical Cardiology·J T Gwynne
Sep 23, 1997·Protein Science : a Publication of the Protein Society·A RozekR J Cushley
Jan 13, 2000·Biochemical and Biophysical Research Communications·V GeorgeaudR Barbaras
Jan 12, 2002·Biochemical and Biophysical Research Communications·Guorong Lin, Karin E Bornfeldt
Mar 23, 2000·Journal of Colloid and Interface Science·M MalmstenW G Wood
Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·M Hashimoto
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·C TsopanakisA Tsopanakis
Jan 1, 1987·European Journal of Applied Physiology and Occupational Physiology·E R SkinnerR J Maughan
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·M Hashimoto, S Masumura
Jan 1, 1982·European Journal of Applied Physiology and Occupational Physiology·P A FarrellA S Leon
Jan 1, 1985·European Journal of Applied Physiology and Occupational Physiology·E R SkinnerR J Maughan
Jan 1, 1983·European Journal of Clinical Pharmacology·S Rössner, L Weiner
Jan 1, 1982·Human Genetics·B K SuarezR S Sparkes
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·L M Hubinger, L T Mackinnon
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·H E PayA Hudson
Feb 17, 1993·Molecular and Cellular Biochemistry·N TadaK Kurosaka
Oct 1, 1993·Journal of Protein Chemistry·Z W GuC Y Yang
May 1, 1988·Archives of Environmental Contamination and Toxicology·J W Carter, S I Koo
Jan 1, 1993·International Journal of Legal Medicine·A F HernandezE Villanueva
Aug 1, 1977·Diabetologia·M F Lopes-VirellaJ A Colwell
Oct 1, 1980·Klinische Wochenschrift·V W ArmstrongF Scheler
Feb 1, 1986·Bulletin of Environmental Contamination and Toxicology·H M Dutta, A Z Haghighi
Jan 1, 1988·Journal of Inherited Metabolic Disease·A Salter, D N Brindley
Mar 1, 1990·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·K SinghS S Ratnam
Dec 1, 1983·Clinical Rheumatology·D HeldenbergM Yaron
Jul 1, 1981·Acta diabetologica latina·C VerganiP M Mannucci
Jul 1, 1996·Clinical Rheumatology·A BakkalogluN Beşbaş
Mar 1, 1997·Clinical Rheumatology·S Rantapää-DahlqvistB Stegmayr


Jan 1, 1977·Advances in Experimental Medicine and Biology·N E MillerP Clifton-Bligh
Jun 12, 1975·European Journal of Clinical Investigation·N E Miller, P J Nestel
Nov 29, 1973·Biochimica Et Biophysica Acta·O Stein, Y Stein
Jan 1, 1973·Atherosclerosis·H S SodhiL Horlick
Feb 1, 1970·Journal of Chronic Diseases·D W Simborg
Oct 1, 1968·The American Journal of Medicine·E H StrisowerB Strisower
May 1, 1969·Circulation·D B HunninghakeD L Azarnoff
Sep 1, 1966·British Heart Journal·G L Mills, P A Wilkinson

Related Concepts

Total cholesterol
Catabolic Process
Body Excretions
Excretory Function
Histiocytosis With Joint Contractures and Sensorineural Deafness

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.