Plasma HMGB-1 Levels in Subjects with Obesity and Type 2 Diabetes: A Cross-Sectional Study in China

PloS One
Hang WangHuacong Deng

Abstract

To detect the levels of plasma High-Mobility Group Box-1(HMGB1) in Chinese subject with obesity and type 2 diabetes mellitus (T2DM), and to investigate the correlations between plasma HMGB1 concentration and parameters of body fat, insulin resistance (IR) metabolism and inflammation. This study recruited 79 normal glucose tolerance (NGT) subjects and 76 newly diagnosed T2DM patients. NGT and T2DM groups were divided into normal weight (NW) and obese (OB)subgroups respectively. Anthropometric parameters such as height, weight, waist circumference, hip circumference and blood pressure were measured. Plasma concentrations of HMGB1, IL-6, fasting plasma glucose (FPG), 2 hours post challenge plasma glucose (2hPG), serum lipid, glycated hemoglobin (HbA1C) and fasting insulin (FINS) were examined. The homeostasis model assessment (HOMA) was performed to assess IR status. Plasma HMGB1 levels were higher in T2DM group than that in NGT group. The concentrations of serum HMGB1 were also higher in subjects with OB than those in subjects with NW both in NGT and T2DM groups. Plasma levels of HMGB1 were positively correlated with waist hip ratio (WHR), blood pressure, FPG, FINS, HOMA-IR, TG, IL-6 and negatively correlated with HOMA-βand high-...Continue Reading

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Citations

Nov 21, 2015·International Journal of Cardiology·Zhaowei Zhu, Xinqun Hu
Apr 3, 2016·Journal of Diabetes and Its Complications·Roma Pahwa, Ishwarlal Jialal
May 26, 2016·Antioxidants & Redox Signaling·Olga Gorelenkova MillerJohn J Mieyal
Mar 28, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M ErdalE Öztas
Dec 15, 2019·International Journal of Molecular Sciences·Federico BiscettiAndrea Flex
Feb 15, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francesca CirilloMaria E Street
May 3, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhaowei ZhuShenghua Zhou
Jan 20, 2017·Journal of Diabetes Research·Yanan WangBoxu Ren
Nov 17, 2016·Mediators of Inflammation·Han WuBiao Xu
Apr 10, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francesca CirilloMaria E Street
Dec 18, 2020·Immunity, Inflammation and Disease·Yunfei Luo, Hui Lin
Apr 30, 2021·Frontiers in Cell and Developmental Biology·Vincenza FrisardiMaria Elisabeth Street
Dec 22, 2017·Journal of Medicinal Chemistry·Sonya VanPatten, Yousef Al-Abed

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Methods Mentioned

BETA
enzyme-linked
ELISA

Software Mentioned

SPSS

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