PMID: 11605787Oct 19, 2001Paper

Plasma homocysteine concentration in children with chronic renal failure

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Aicha MerouaniRima Rozen

Abstract

Hyperhomocysteinemia, a risk factor for vascular disease, is commonly found in adult patients with end-stage renal disease. Major determinants of elevated plasma homocysteine levels in these patients include deficiencies in folate and vitamin B12, methylenetetrahydrofolate reductase (MTHFR) genotype and renal function. Little information is available for children with chronic renal failure (CRF). The prevalence and the factors that affect plasma homocysteine concentration were determined in children. Twenty-nine children with various degrees of CRF (15 were dialyzed, 14 were not dialyzed) were compared with 57 age- and sex-matched healthy children. Homocysteine concentrations were higher in patients than controls (17.3 micromol/l vs 6.8 micromol/l, P<0.0001) and hyperhomocysteinemia (>95th percentile for controls: 14.0 micromol/l) was seen in 62.0% of patients and 5.2% of controls. Folate concentrations were lower in patients (9.9 nmol/l) than controls (13.5 nmol/l), P<0.01. Vitamin B12 was similar in patients (322 pmol/l) and controls (284 pmol/l). Dialyzed patients have a higher prevalence of hyperhomocysteinemia than nondialyzed patients (87% vs 35%). Dialyzed patients with MTHFR mutation have higher plasma homocysteine (28....Continue Reading

Citations

Dec 16, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rulan S Parekh, Samuel S Gidding
Sep 1, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Oluwatoyin Fatai Bamgbola, Frederick Kaskel
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