Plasma homocysteine levels are associated with ulceration of the foot in patients with type 2 diabetes mellitus

Diabetes/metabolism Research and Reviews
R GonzálezR Carmena

Abstract

To examine the association of biochemical markers of risk (plasma Hcy, microalbuminuria, lipoprotein (a)(Lp(a)) and diabetic dyslipidaemia) with the prevalence of diabetic foot ulceration in type 2 diabetic patients. Case/control study conducted in 198 type 2 diabetic patients. 89 patients have foot ulcers and 109 have no foot ulcers (control group), in order to establish ORs for diabetic foot ulceration. In all subjects plasma Hcy, Lp(a), total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein B, HbA(1c) and microalbuminuria were measured using standard procedures. Plasma Hcy, microalbuminuria, HbA(1c) and apolipoprotein B levels were significantly higher in patients with foot ulceration compared with the control group. Plasma lipids, Lp(a), vitamin B12 and folic acid values were similar in both groups. In the logistic regression model, plasma Hcy (OR 1.09; 95% CI 1.04-1.69), microalbuminuria (OR 1,01; 95% CI 1.01-1.17) and HbA(1c) levels (OR 1.33; 95% CI 1.04-1.69) were independent risk factors for the presence of diabetic foot ulceration. In our study, for each micromol increase in plasma Hcy levels there was a 10% increase in the risk of diabetic foot ulcer...Continue Reading

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Citations

Aug 5, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shi-Sheng ZhouYong-Zhi Lun
May 23, 2014·Journal of Diabetes and Its Complications·Erli PeiMaoquan Li
Dec 18, 2012·Acta Diabetologica·Mehmet Ali ErenNurten Aksoy
Dec 24, 2013·Journal of Diabetes and Its Complications·Anne Karin MolværMarjolein M Iversen
Oct 7, 2014·Cardiovascular Diabetology·Antonysunil AdaikalakoteswariPonnusamy Saravanan
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Jan 10, 2021·Journal of Diabetes and Its Complications·Emir MuzurovićDimitri P Mikhailidis

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