PMID: 45502Apr 1, 1978

Plasma hypoxanthine in neonatal hypoxia: a comparison of two methods

European Journal of Obstetrics, Gynecology, and Reproductive Biology
P GuicheneyG Olive


Hypoxanthine levels were determined in both venous and arterial cord blood of 42 neonates. Two methods were compared, a PO2 electrode determination and an HPLC (high-pressure liquid chromatography) method. A good correlation was found between the two methods. However, the HPLC method was more sensitive, more reproducible and easier to perform. Hypoxanthine levels in the umbilical artery were found to be higher than in the vein. A significant negative correlation between pH and hypoxanthine level was established. The studies showed that plasma hypoxanthine levels by themselves did not provide an absolute diagnosis of intrauterine hypoxia.


Apr 1, 1975·Pediatric Research·O D Saugstad
Jul 1, 1975·Pediatric Research·O D Saugstad


Nov 19, 2011·Purinergic Signalling·Nicholas Dale, Bruno G Frenguelli
Jun 1, 1992·American Journal of Respiratory Cell and Molecular Biology·P M HassounB L Fanburg

Related Concepts

Blood Gas Analysis
High Pressure Liquid Chromatography Procedure
Umbilical Cord Blood
Hydrogen-Ion Concentration

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