Plasma IL-8 concentrations are increased in dogs with spirocercosis

Veterinary Parasitology
Eran DvirJ P Schoeman

Abstract

The nematode Spirocerca lupi (S. lupi) induces sarcoma in the dog oesophagus in about 25% of cases. The aim of this study was to compare the differences in the cytokine milieu between dogs with neoplastic (n=29) and non-neoplastic disease (n=49) and age- and gender-matched healthy controls (n=25). We measured IL-2, IL-4, IL-6, IL-8, IL-10, IL-18, GM-CSF and MCP-1 in a specific canine multiplex immunoassay kit. Cytokine concentrations were compared between the different groups using the Kruskal-Wallis test followed by Dunn's test. Only IL-8 and IL-18 showed significant differences in their plasma concentration among the three groups. Kruskal-Wallis test revealed a significant (p=0.001) difference in IL-8 concentration between the neoplastic group (634pg/ml), the non-neoplastic (429 pg/ml) and the control groups (150 pg/ml). Post-test analysis revealed a significance difference between the two S. lupi groups and the control group (p<0.01). The highest IL-18 concentration was found in the non-neoplastic group (53 pg/ml), followed by the control group (46 pg/ml) and finally the neoplastic group (33 pg/ml). IL-18 concentrations were significantly higher in the non-neoplastic group than in the neoplastic group (p=0.05). The increased...Continue Reading

References

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Citations

Aug 21, 2013·Journal of Veterinary Internal Medicine·C T RosaE Dvir
Jan 10, 2013·Veterinary Parasitology·Robert M KirbergerEran Dvir
Aug 16, 2017·Veterinary Pathology·Kristen R RichterAngela M Mexas
Nov 25, 2017·Journal of Veterinary Emergency and Critical Care·Clara B MarschnerAnnemarie T Kristensen

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