PMID: 8602665Feb 1, 1996Paper

Plasma inorganic fluoride concentrations after sevoflurane anesthesia in children

Anesthesiology
M F LevineD R Cook

Abstract

Sevoflurane is degraded in vivo in adults yielding plasma concentrations of inorganic fluoride [F-] that, in some patients, approach or exceed the 50- micron theoretical threshold for nephrotoxicity. To determine whether the plasma concentration of inorganic fluoride [F-] after 1-5 MAC x h sevoflurane approaches a similar concentration in children, the following study in 120 children scheduled for elective surgery was undertaken. Children were randomly assigned to one of three treatment groups before induction of anesthesia: group 1 received sevoflurane in air/oxygen 30% (n = 40), group 2 received sevoflurane in 70% N2O/30% O2 (n = 40), and group 3 received halothane in 70% N2O/30% O2 (n = 40). Mapleson D or F circuits with fresh gas flows between 3 and 61/min were used Whole blood was collected at induction and termination of anesthesia and at 1, 4, 6, 12, and 18 or 24 h postoperatively for determination of the [F-]. Plasma urea and creatinine concentrations were determined at induction of anesthesia and 18 or 24 h postoperatively. The mean (+/- SD) duration of sevoflurane anesthesia, 2.7 +/- 1.6 MAC x h (range 1.1-8.9 MAC x h), was similar to that of halothane, 2.5 +/- 1.1 MAC x h. The peak [F-] after sevoflurane was recorded...Continue Reading

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Citations

Feb 15, 2002·Anaesthesia·C LejusM Pinaud
Mar 2, 2002·Anaesthesia·D G MaloneyR S Vaughan
Jul 20, 1999·Paediatric Anaesthesia·J Holzki, F J Kretz
Oct 24, 2002·British Journal of Anaesthesia·C LejusM Pinaud
Jan 18, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert A WermersThomas P Moyer
Oct 31, 1998·Annals of Emergency Medicine·D Bracco, J B Favre
May 20, 2003·Best Practice & Research. Clinical Anaesthesiology·Florian M Reichle, Peter F Conzen
Feb 7, 1998·Anaesthesia and Intensive Care·S M WalkerA Richards
Jul 15, 2020·Human & Experimental Toxicology·A M EmaraR M Elgarabawy
Aug 20, 2020·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Rakesh V SondekoppamTimur J-P Özelsel
Feb 23, 2021·Journal of Immunotoxicology·Ashraf Mahmoud EmaraRehab Mohamed Elgharabawy

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