Plasma insulin in response to enterostatin and effect of adrenalectomy in rats

Obesity Research
J Mei, C Erlanson-Albertsson

Abstract

Enterostatin has previously been reported to alter serum insulin and corticosterone levels after central administration of the peptide. The purpose of the present study was to investigate the effect of peripheral administration of enterostatin on insulin and corticosterone levels as well as the response of plasma insulin to enterostatin administration in adrenalectomized rats. Female Sprague-Dawley rats were given a bolus injection intravenously with enterostatin alone or together with glucose. Enterostatin increased basal plasma levels of insulin, but significantly inhibited the increase in plasma insulin stimulated by glucose. Plasma corticosterone levels were not altered after a single intravenous injection of enterostatin. In rats infused chronically with enterostatin, plasma insulin levels were significantly reduced and plasma corticosterone levels were increased. The daily food intake was lower in these rats, but there was no effect on body weight. After adrenalectomy, the responsiveness of plasma insulin to enterostatin infusion was completely abolished. Furthermore, adrenalectomy itself reduced basal plasma levels of insulin and increased plasma levels of endogenous enterostatin. These results suggest that peripheral en...Continue Reading

References

Apr 8, 1992·Biochimica Et Biophysica Acta·C Erlanson-Albertsson
Aug 30, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·R C BowyerJ Hermon-Taylor
Jun 1, 1991·Physiology & Behavior·C Erlanson-AlbertssonG A Bray
May 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M R FreedmanC E Mondon
Sep 1, 1994·Acta Diabetologica·C Erlanson-AlbertssonK Federlin
Jun 15, 1993·The Biochemical Journal·S OkadaG A Bray
Jul 1, 1993·Catheterization and Cardiovascular Diagnosis·S K AgarwalG S Roubin
Mar 1, 1996·Obesity Research·J Mei, C Erlanson-Albertsson
May 1, 1993·Obesity Research·L LinG A Bray

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Citations

Jul 8, 2003·The British Journal of Nutrition·Eva M R KovacsMargriet S Westerterp-Plantenga
Jul 1, 1997·Obesity Research·C Erlanson-Albertsson, D York

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