PMID: 9438850Feb 7, 1998Paper

Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study

Science
J M ChanM Pollak

Abstract

Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases and 152 controls. A strong positive association was observed between IGF-I levels and prostate cancer risk. Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment.

References

Aug 1, 1991·The Journal of Clinical Endocrinology and Metabolism·P CohenR G Rosenfeld
Aug 31, 1990·Science·S M Cohen, L B Ellwein
Nov 7, 1990·Journal of the National Cancer Institute·M PollakR Margolese
Feb 15, 1990·International Journal of Cancer. Journal International Du Cancer·C La VecchiaS Franceschi
Jul 5, 1990·The New England Journal of Medicine·D RudmanD E Mattson
Jul 1, 1995·Epidemiology·G TibblinA Ekbom
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·M ZarandiA V Schally
Feb 1, 1994·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P CohenR G Rosenfeld
Aug 21, 1996·Journal of the National Cancer Institute·P H GannM J Stampfer
Mar 5, 1997·Journal of the National Cancer Institute·S O AnderssonO Nyrén
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·E GiovannucciP W Kantoff
Jun 1, 1997·American Journal of Epidemiology·D Goodman-Gruen, E Barrett-Connor
Jul 1, 1997·Cancer Causes & Control : CCC·P R HebertC H Hennekens
Jan 1, 1997·British Journal of Cancer·C S MantzorosH O Adami
Feb 6, 1998·Proceedings of the Society for Experimental Biology and Medicine·M N Pollak, A V Schally

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Citations

Feb 25, 2009·Archives of Internal Medicine·Yikyung ParkArthur Schatzkin
Feb 11, 1999·The Prostate·E ReiterG Hennen
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·E PetridouD Trichopoulos
Feb 27, 1999·International Journal of Cancer. Journal International Du Cancer·C C HsiehD Trichopoulos
Aug 17, 1999·International Journal of Cancer. Journal International Du Cancer·O ManousosC Mantzoros
Jun 22, 2000·The Prostate·G Pirtskhalaishvili, J B Nelson
Oct 12, 2000·The Prostate·A V SchallyZ Rekasi
Mar 27, 2001·International Journal of Cancer. Journal International Du Cancer·B D LiH Yu
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·S O StuverD Trichopoulos
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Bas A J VerhageJack A Schalken
Sep 19, 2002·International Journal of Cancer. Journal International Du Cancer·Annekatrin LukanovaRudolf Kaaks
May 15, 2001·International Journal of Cancer. Journal International Du Cancer·A LukanovaR Kaaks
Oct 2, 2002·Journal of Surgical Oncology·Kevin DeitelRobert Bell
Jul 12, 2002·The Prostate·Anand P ChokkalingamAnn W Hsing
Aug 8, 2002·Phytotherapy Research : PTR·Xin ChenM Zack Howard
Nov 19, 2004·Der Urologe. Ausg. A·F MayR Hartung
Apr 14, 2007·International Orthopaedics·Aziz AbbaspourNatsuo Yasui
Jan 16, 2007·Journal of Cancer Research and Clinical Oncology·P KanagarajJ Arunakaran
Nov 19, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Joachim WoelflePeter Rotwein
Jan 12, 2008·Journal of Human Genetics·Xin ChenQihan Wu
Jun 11, 2005·Cancer Causes & Control : CCC·Elizabeth A PlatzEdward Giovannucci
Sep 1, 2005·Cancer Causes & Control : CCC·Cathrine HoyoJoellen M Schildkraut
Aug 26, 2006·Cancer Causes & Control : CCC·Clareann H BunkerJane A Cauley
Mar 15, 2008·Cancer Causes & Control : CCC·Jocelyn S KasperEdward Giovannucci
Dec 19, 2008·Cancer Causes & Control : CCC·Yuqing ZhangLynn Rosenberg
Dec 21, 2011·Cancer Causes & Control : CCC·Mari-Anne RowlandsRichard M Martin

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