PMID: 10871567Jun 29, 2000Paper

Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate

The American Journal of Clinical Nutrition
Luc J C van LoonAnton J Wagenmakers

Abstract

Protein induces an increase in insulin concentrations when ingested in combination with carbohydrate. Increases in plasma insulin concentrations have been observed after the infusion of free amino acids. However, the insulinotropic properties of different amino acids or protein (hydrolysates) when co-ingested with carbohydrate have not been investigated. The aim of this study was to define an amino acid and protein (hydrolysate) mixture with a maximal insulinotropic effect when co-ingested with carbohydrate. Eight healthy, nonobese male subjects visited our laboratory, after an overnight fast, on 10 occasions on which different beverage compositions were tested for 2 h. During those trials the subjects ingested 0.8 g*kg(-)(1)*h(-)(1) carbohydrate and 0.4 g*kg(-)(1)*h(-)(1) of an amino acid and protein (hydrolysate) mixture. A strong initial increase in plasma glucose and insulin concentrations was observed in all trials, after which large differences in insulin response between drinks became apparent. After we expressed the insulin response as area under the curve during the second hour, ingestion of the drinks containing free leucine, phenylalanine, and arginine and the drinks with free leucine, phenylalanine, and wheat protei...Continue Reading

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Citations

Mar 19, 2002·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·J L Ivy
Mar 6, 2003·Sports Medicine·Roy Jentjens, Asker Jeukendrup
Jul 28, 2004·The American Journal of Clinical Nutrition·Sabine WestphalClaus Luley
Nov 30, 2006·Diabetes·Jean-Claude HenquinMyriam Nenquin
Apr 3, 2007·The British Journal of Nutrition·C Jeya K HenryJacqueline M Wynne
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jacqueline Carvalho-PeixotoLuiz-Claudio Cameron
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Oct 12, 2011·Medicine and Science in Sports and Exercise·Milou BeelenLuc J C van Loon
Nov 1, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Luc J C van Loon
Dec 23, 2011·The American Journal of Clinical Nutrition·Thomas M S Wolever, Kalpana Bhaskaran
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