Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic sujbjects

The Journal of Clinical Investigation
M J Perley, D M Kipnis

Abstract

The plasma insulin responses of normal weight and obese, diabetic, and nondiabetic subjects to intravenous glucose was only 30-40% of that seen after oral glucose, indicating that alimentary mechanism(s) in addition to the arterial blood sugar concentration regulate insulin secretion. Observations made in subjects with diverted portal circulation indicate that the alimentary insulinogenic mechanism is located in the intestinal tract. The insulinogenic potency of the alimentary and glycemic stimuli expressed in terms of insulin secretion per gram of glucose were remarkably similar within each group of individuals. Between these groups, however, there were considerable differences. Obesity, with or without associated diabetes, was associated with a true hypersecretory responsiveness, whereas diabetes was characterized, with or without obesity, by a marked impairment in insulin secretion. The experimental design used in these studies permitted quantitation of the magnitude of the glycemic component of an oral glucose load. As a consequence of impaired insulin secretion, a greater than normal proportion of the oral glucose load escapes initial hepatic extraction in the maturity-onset diabetic and enters the peripheral circulation. ...Continue Reading

References

Oct 8, 1965·Annals of the New York Academy of Sciences·R S YalowS A Berson
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·N McIntyreD S Turner
Jul 22, 1960·Annals of the New York Academy of Sciences·C WELLERG KESSLER
Jul 4, 1964·Lancet·N McIntyreD S Turner
Oct 17, 1964·Lancet·F BALSANOV DINOTO
Oct 1, 1964·The Journal of Clinical Endocrinology and Metabolism·H ELRICKY ARAI
Aug 28, 1965·Lancet·E SAMOLSV Marks

Citations

Jun 20, 2002·Pharmazie in unserer Zeit·Burkhard GökeJörg Schirra
Jul 1, 1992·Diabetes/metabolism Reviews·W Creutzfeldt, M Nauck
Sep 7, 2001·Diabetes/metabolism Research and Reviews·J Radziuk, S Pye
Dec 1, 1970·Diabetologia·N McIntyreC D Holdsworth
Jun 1, 1975·Diabetologia·J F RehfeldK Fischerman
Jan 1, 1979·Diabetologia·J F RehfeldJ J Holst
Apr 1, 1977·Diabetologia·S T McCarthyR C Turner
Mar 1, 1979·Diabetologia·R J Porter, J M Bassett
Aug 1, 1977·Diabetologia·W HeptnerJ P Felber
Feb 1, 1979·Diabetologia·W Creutzfeldt
Apr 1, 1972·Diabetologia·M FahlénP Björntorp
Jan 1, 1987·Journal of Inherited Metabolic Disease·I AntonozziR Dominici
Mar 1, 1971·Naika. Internal medicine·K Kosaka
Jan 1, 1980·Annals of Biomedical Engineering·J V Santiago, N H White
Jan 1, 1986·Diabetologia·Michael A NauckW Creutzfeldt
Jan 1, 1982·Acta diabetologica latina·B BeckG Debry
May 1, 1975·Acta diabetologica latina·F FalluccaD Andeani
Apr 1, 1983·Acta diabetologica latina·M Rendell
Nov 1, 1972·Canadian Anaesthetists' Society Journal·E A MoffittK Rehder
Mar 5, 2008·Diabetologia·Juris J Meier
Mar 30, 2007·Annals of Biomedical Engineering·Patricia L BrubakerKenneth H Norwich
Apr 5, 2013·Frontiers of Medicine·Bing LiHuarong Zhou
Mar 20, 2003·Current Diabetes Reports·M Angelyn Bethel, Mark N Feinglos
Aug 11, 2006·Current Diabetes Reports·Juris J Meier, Michael A Nauck
Apr 29, 2010·Current Diabetes Reports·Liam R BrunhamC Bruce Verchere

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