Plasma interleukin-1alpha, interleukin-1beta and interleukin-1 receptor antagonist levels in pre-eclampsia

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Y KimyaF Sengül

Abstract

The values of plasma interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1ra) levels were evaluated as the markers of pre-eclampsia in 35 serial plasma samples from ten pregnant women who subsequently developed pre-eclampsia and in 74 plasma samples from 20 uncomplicated pregnancies, retrospectively. No correlation was found between plasma IL-1alpha, IL-1beta and IL-1ra levels, liver and renal function tests, thrombocyte and white blood cell counts, proteinuria, systolic and diastolic blood pressures and gestational weeks. Almost equal levels of IL-1alpha and IL-1beta were measured in all corresponding groups, but these were too few in number to statistically analyze. IL-1ra values were higher in the pre-eclampsia group than in the uncomplicated pregnancy group, at 20-25 and 31-35 gestational weeks significantly and 26-30 gestational weeks insignificantly and showed an increase during labor in both groups. It was found to have 58% positive predictivity, 100% negative predictivity, 50% specificity and 100% sensitivity at gestational weeks 20-25. According to these results, IL-1ra seems to be considered for its high negative predictivity in the exclusion of the probability of pre...Continue Reading

Citations

Apr 28, 2012·American Journal of Reproductive Immunology : AJRI·Edward MullinsSailesh Kumar
Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Augusta M A LachmeijerLeo P ten Kate
Jun 15, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ysabel C CasartMaría I Camejo
Aug 23, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alaa AmashMahmoud Huleihel
Sep 29, 2018·American Journal of Reproductive Immunology : AJRI·Ioannis BellosCharalampos Siristatidis
May 21, 2014·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Peng ChenLin Zhang
Feb 20, 2015·Clinical and Experimental Immunology·J H SouthcombeI Granne
Nov 12, 2015·The Journal of Obstetrics and Gynaecology Research·Saeedeh SalimiFarzaneh Farajian-Mashhadi

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