PMID: 571211Jan 1, 1979Paper

Plasma kinetics and urinary excretion of exogenous human and salmon calcitonin in man

The American Journal of Physiology
R HuwylerJ A Fischer


The metabolism and the urinary excretion of synthetic human and salmon calcitonin-(1--32) [hCT-(1--32), sCT-(1--32)] administered by constant infusions for 240 min were investigated in eight normal subjects. On gel filtration of plasma obtained during the infusions mainly intact hCT-(1--32) and sCT-(1--32) were recognized with homologous radioimmunoassay systems. During constant infusions to equilibrium of 0.04 mg hCT-(1--32) and sCT-(1--32), the metabolic clearance rates (MCR) amounted to 8.4 +/- 1.1 and 3.1 +/- 0.1 ml/kg per min, respectively (P less than 0.01). When hCT-(1--32) was infused at rates of 1 and 4 mg/240 min, the MCR were lower than with 0.04 mg hCT-(1--32), but still higher than with 0.04 mg sCT-(1--32). The half-lives of disappearance of hCT-(1--32) were faster compared to sCT-(1--32), but the difference was not statistically significant. The urinary clearance of hCT-(1--32) determined during the 1 and 4 mg/240 min infusions of hCT-(1--32), as well as of sCT-(1--32) determined during the 0.04-mg infusions of sCT-(1--32) was about 0.1% of the MCR. The half-lives of disappearance of hCT- and sCT-(1--32) incubated in vitro in plasma and urine ranged from 17 to more than 72 h, and the degradation did not affect our...Continue Reading


Jan 1, 1977·Annual Review of Medicine·W G Ryan
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J MoranJ A Fischer
Apr 1, 1978·The Journal of Endocrinology·C McMartin, G E Purdon
May 1, 1977·Endocrinology·P J ScarpaceL G Raisz
Nov 27, 1974·Biochemical and Biophysical Research Communications·F R Singer, J F Habener
Jun 28, 1972·Nature: New Biology·F R SingerJ T Potts
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Apr 1, 1973·Endocrinology·F E NewsomeD H Copp
May 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R ArdaillouG Vallée
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Oct 31, 1968·Helvetica Chimica Acta·B RinikerI MacIntyre

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