PMID: 11334360May 4, 2001Paper

Plasma L-arginine is markedly reduced in pregnant women affected by preeclampsia

Journal of Chromatography. B, Biomedical Sciences and Applications
G D'AnielloG Fisher

Abstract

The objective of this study was to determine the concentration of free L-amino acids and in particular of L-arginine in the plasma of pregnant women affected by preeclampsia compared to healthy pregnant women in order to know if an alteration in the concentrations of these amino acids occurs in preeclamspia. Twelve pregnant women affected by preeclampsia and twelve pregnant control women, ages 28-35 years old and at the 35-36 weeks of pregnancy were studied. The blood analysis of free amino acids was carried out by using a high performance liquid chromatographic (HPLC) fluorometric method and OPA-NAC as derivatizing agent for the amino acid determination. In the blood of women affected by preeclampsia L-arginine is markedly reduced compared to controls (about five-fold lower, P<0.01). The other amino acids also are significantly reduced, but to lesser extents (about 1.5 times lower, P<0.05). Thus, the determination of L-arginine in the blood of pregnant women could potentially constitute an additional marker for the early diagnosis of preeclampsia.

References

Oct 21, 1993·The New England Journal of Medicine·F P Zuspan, P Samuels

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Citations

Mar 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Robert H GlewDorothy J VanderJagt
Oct 1, 2012·Pregnancy Hypertension·Yurbi TeránPedro Rada
Aug 4, 2015·Journal of Clinical Biochemistry and Nutrition·Jingwen WangFumitaka Kikkawa
Mar 24, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Breno José Acauan FilhoCarlos Eduardo Poli-de-Figueiredo
Dec 18, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Anne Cathrine StaffTore Henriksen
Sep 17, 2004·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·May Lee TjoaInge J van Wijk
Feb 11, 2004·Hypertension·Barbara T AlexanderJoey P Granger
May 6, 2003·The Journal of Nutrition·James M RobertsAnibal Martinez
Aug 13, 2008·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Elizabeth TurnerJulie Fisher

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