PMID: 1932105Nov 5, 1991Paper

Plasma lecithin-cholesterol acyltransferase activity and cholesterol and phospholipid levels in premature newborn infants

Biochimica Et Biophysica Acta
S K Jain, J J Diaz


Lecithin-cholesterol acyltransferase (LCAT) activity has been suggested to play an important role in the regulation of lipid metabolism. The present study was undertaken to examine any relationship between LCAT activity and altered cholesterol levels in plasma of full-term and preterm newborn infants. Plasma total, free and esterified cholesterol, total phospholipid and LCAT activity (cholesterol esterified, nmol/ml per h) were determined in placental cord blood. There was a significant negative relationship between total cholesterol levels and gestational age. The increased cholesterol with prematurity was due to both free and esterified cholesterol. There was also a significant negative relationship between LCAT activity and free cholesterol levels but not between LCAT activity and total cholesterol and esterified cholesterol levels. There was no relationship between esterified-to-free cholesterol ratio and LCAT activity. Total phospholipid was not significantly related to either gestational age or LCAT activity. This study suggests that reduced LCAT activity may be one of the factors that result in the accumulation of cholesterol in premature infants.


Apr 19, 1975·Lancet·A J BronR C Tripathi
Jul 1, 1977·The Journal of Pediatrics·A T ShennanA Angel
Jun 1, 1971·Metabolism: Clinical and Experimental·C J GlueckW Pearce
Feb 21, 1981·Lancet·G E AndersenI Tygstrup
Apr 1, 1981·The Journal of Pediatrics·R DhanireddyP Hamosh
Sep 1, 1980·Acta paediatrica Scandinavica·B E Ginsburg, R Zetterström
Sep 1, 1983·Metabolism: Clinical and Experimental·C R ParkerP C MacDonald
Aug 1, 1982·Pediatric Research·H J JohnsonR C Parker
Nov 1, 1980·The Journal of Pediatrics·B B Dahms, T C Halpin


Aug 7, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·C SimoensY A Carpentier
Sep 13, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jolanta E Damas, Max H Cake

Related Concepts

Gestational Age
Neonatal Prematurity
Phosphatidylcholine-Sterol O-Acyltransferase

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