PMID: 18727209Aug 30, 2008Paper

Plasma leptin levels in pigs with different leptin and leptin receptor genotypes

Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie
M AmillsJ Estany

Abstract

A C3469T mutation at exon 3 of the pig leptin (Lep) gene has been genotyped in diverse pig breeds yielding controversial results with regard to its association with growth, fatness and carcass traits. A similar situation has been reported for a HpaII restriction fragment length polymorphism (RFLP) in the pig leptin receptor (Lepr) gene, where associations were found depending on the statistical model employed. The main objective of our work was to investigate if leptin plasma concentrations differ in pigs with different C3469T and Lepr HpaII RFLP genotypes. With this aim, we have measured plasma leptin levels at 160 days in 68 Landrace pigs with different Lep C3469T and Lepr HpaII RFLP genotypes. Neither Lep (TT: 11.68 ng/ml, TC: 10.71 ng/ml) nor Lepr (AA: 12.6 ng/ml, AB: 10.93 ng/ml, BB: 11.74 ng/ml) genotypes influenced significantly plasma Lep concentration. Moreover, we did not find any association between Lep and Lepr genotypes and phenotypic variation at growth and fatness traits in a commercial population of 320 Landrace pigs.

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Citations

Dec 4, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Cristina OviloLuis Silió
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·A R G Wylie
May 7, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Johanna SamulinHilde Sundvold
Mar 23, 2012·Animal Science Journal = Nihon Chikusan Gakkaihō·Yoshinobu UemotoKeiichi Suzuki

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