PMID: 9523542Apr 2, 1998Paper

Plasma leukocyte elastase concentration and coronary artery disease

Angiology
F KoşarE Diker

Abstract

It has previously been shown that leukocyte elastase is involved in the pathogenesis of atherosclerosis. Few studies have addressed the relation between leukocyte elastase concentrations and coronary artery disease (CAD). The authors investigated (1) the clinical significance of leukocyte elastase determination in the diagnosis of CAD and (2) the relation between plasma leukocyte elastase concentration and lesion morphology. The study included 185 subjects (140 men, 45 women) who underwent coronary angiography during investigation of chest pain; 135 had coronary stenosis (Group I) and 50 had nonstenotic coronaries (Group II). Among Group I patients, those with simple atheromatous plaques were distinguished from those with complex plaques. Elastase concentrations in Group I were greater than in Group II (57.1 +/- 1.16 micrograms I[-1] vs 27.6 +/- 1.0 microgram, I[-1], P<0.001), and greater in complex plaque patients than in those with simple plaques (64.5 +/- 1.24 micrograms I[-1] vs 45.9 +/- 1.01 micrograms I[-1], P<0.001). Logistic regression analysis showed (1) that elastase concentration, age, and sex had independent value for prediction of CAD and (2) that among Group I patients, the risk of complex plaques was greatest for...Continue Reading

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Citations

Apr 2, 2004·Biochimica Et Biophysica Acta·Anton PoliakovU Helena Danielson
Apr 3, 2004·Trends in Molecular Medicine·Marshall HorwitzRichard E Person
May 24, 2003·Experimental Hematology·Andrew A G AprikyanDavid C Dale
Jun 29, 2001·Pathologie-biologie·M P JacobJ B Michel
Jul 31, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marie Paule Jacob
Sep 7, 2001·Current Opinion in Immunology·A A Aprikyan, D C Dale
Jun 7, 2013·Thrombosis and Haemostasis·F CarboneF Montecucco
Jan 22, 2008·International Journal of Cardiology·Ibrahim SariMehmet Aksoy
Jan 27, 2004·Journal of Leukocyte Biology·C D GarlichsW G Daniel
Feb 14, 2018·Journal of the American Heart Association·Guanmei WenQingzhong Xiao
Dec 10, 2021·PloS One·Saumya BhagatGausal A Khan

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