Abstract
It has previously been shown that leukocyte elastase is involved in the pathogenesis of atherosclerosis. Few studies have addressed the relation between leukocyte elastase concentrations and coronary artery disease (CAD). The authors investigated (1) the clinical significance of leukocyte elastase determination in the diagnosis of CAD and (2) the relation between plasma leukocyte elastase concentration and lesion morphology. The study included 185 subjects (140 men, 45 women) who underwent coronary angiography during investigation of chest pain; 135 had coronary stenosis (Group I) and 50 had nonstenotic coronaries (Group II). Among Group I patients, those with simple atheromatous plaques were distinguished from those with complex plaques. Elastase concentrations in Group I were greater than in Group II (57.1 +/- 1.16 micrograms I[-1] vs 27.6 +/- 1.0 microgram, I[-1], P<0.001), and greater in complex plaque patients than in those with simple plaques (64.5 +/- 1.24 micrograms I[-1] vs 45.9 +/- 1.01 micrograms I[-1], P<0.001). Logistic regression analysis showed (1) that elastase concentration, age, and sex had independent value for prediction of CAD and (2) that among Group I patients, the risk of complex plaques was greatest for...Continue Reading
References
Sep 3, 1991·The American Journal of Cardiology·J A Ambrose, D H Israel
Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A M HenneyS Humphries
Jun 1, 1990·Journal of the American College of Cardiology·J L DinermanA Davidson
Mar 1, 1989·Circulation·J MehtaR Wallin
Aug 1, 1989·British Journal of Obstetrics and Gynaecology·I A GreerA A Calder
Apr 1, 1986·The Journal of Clinical Investigation·L A SmedlyG S Worthen
Nov 1, 1987·Annals of Internal Medicine·J I WeitzJ Yu
Sep 8, 1987·Biochemistry·D J Pipoly, E C Crouch
Dec 1, 1986·Circulation·S EllisE L Alderman
Nov 1, 1965·The Journal of Experimental Medicine·A JanoffM A Bean
Aug 16, 1968·Science·A Janoff, J D Zeligs
Dec 1, 1981·The Journal of Clinical Investigation·J M HarlanD G Wright
May 1, 1995·European Heart Journal·A AmaroM Gil
Jan 1, 1962·Journal of Atherosclerosis Research·B SHORE, V SHORE
Citations
Apr 20, 2000·Journal of Invertebrate Pathology·N T BrunA D Boghen
Apr 2, 2004·Biochimica Et Biophysica Acta·Anton PoliakovU Helena Danielson
Apr 3, 2004·Trends in Molecular Medicine·Marshall HorwitzRichard E Person
May 24, 2003·Experimental Hematology·Andrew A G AprikyanDavid C Dale
Jun 29, 2001·Pathologie-biologie·M P JacobJ B Michel
Jul 31, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marie Paule Jacob
Sep 7, 2001·Current Opinion in Immunology·A A Aprikyan, D C Dale
May 9, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·S C KarahanE Onder
Jun 7, 2013·Thrombosis and Haemostasis·F CarboneF Montecucco
Jan 24, 2007·Heart, Lung & Circulation·Serkan TopalogluSule Korkmaz
Jan 22, 2008·International Journal of Cardiology·Ibrahim SariMehmet Aksoy
Jan 27, 2004·Journal of Leukocyte Biology·C D GarlichsW G Daniel
Feb 14, 2018·Journal of the American Heart Association·Guanmei WenQingzhong Xiao
Jun 3, 2021·British Journal of Pharmacology·Mei YangLi Zhang
Aug 27, 2021·Annals of Vascular Surgery·Dong-Jin OhHye Min Choi
Dec 10, 2021·PloS One·Saumya BhagatGausal A Khan