Aug 1, 1994

Plasma level and gene polymorphism of angiotensin-converting enzyme in relation to myocardial infarction

Circulation
F CambienG Luc

Abstract

The angiotensin-converting enzyme (ACE) plays an important role in the production of angiotensin II and the degradation of bradykinin, two peptides involved in cardiovascular homeostasy. Presence of a polymorphism in the ACE gene (ACE Ss) has been postulated from segregation analysis of plasma ACE in families. This putative polymorphism, which strongly affects the plasma and cellular levels of ACE, probably by modulating ACE gene transcription, has not yet been identified at the molecular level; however, an insertion/deletion polymorphism is present in the 16th intron of the ACE gene (ACE I/D) and appears to be a very good marker for ACE Ss. The biological role of ACE suggests that the ACE gene polymorphism could affect the predisposition to myocardial infarction (MI). We have recently shown, in a large case-control study (ECTIM), that the marker allele D of the ACE gene, which is associated with higher levels of ACE in plasma and cells, was more frequent in male patients with MI than in control subjects, especially in patients considered at low risk. ACE activity has now been measured from frozen aliquots of plasma in a large subsample of the ECTIM study (n = 1086). Plasma ACE level did not differ between patients and control ...Continue Reading

  • References9
  • Citations123

References

  • References9
  • Citations123

Citations

Mentioned in this Paper

Gene Polymorphism
Apolipoproteins B
Gene Deletion Abnormality
Myocardial Infarction
Bradykinin Assay
Angiotensin Converting Enzyme Activity
Hypolipidemic Agents
Body Mass Index Procedure
Deletion Mutation
APOB gene

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