Plasma level of asymmetric dimethylarginine (ADMA) as a predictor of carotid intima-media thickness progression: six-year prospective study using carotid ultrasonography

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Kumiko FurukiTsutomu Imaizumi

Abstract

This study was designed to determine the relationship between plasma asymmetric dimethylarginine (ADMA) and the development of carotid atherosclerosis. Cross-sectional studies have revealed that plasma ADMA concentration is correlated with the intima-media thickness (IMT) of the carotid artery, but no prospective studies have appeared. Therefore we prospectively investigated whether or not plasma ADMA level can predict IMT progression. In a community-based cohort, we enrolled 712 subjects who were over 40 years old and who had no apparent cardiovascular diseases according to high-resolution carotid ultrasonography. Blood chemistries including ADMA were measured at baseline. In 575 subjects, IMT was re-measured 6 years later. The value of baseline ADMA for predicting IMT changes was investigated by multivariable analysis. At baseline, there was a significant (beta=0.321; p<0.001) relationship between IMT and ADMA levels. Multiple linear regression analysis revealed that baseline ADMA (beta=0.241; p<0.01) was the only predictor of IMT progression after adjustments for age, sex, baseline IMT, and four major risk factors (hypertension, hypercholesterolemia, diabetes mellitus, and smoking) plus hyperuricacidemia. Plasma ADMA was a p...Continue Reading

References

Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Mar 4, 1993·The New England Journal of Medicine·J A Ware, D D Heistad
Jan 1, 1997·Annual Review of Medicine·J P Cooke, V J Dzau
Apr 25, 2000·Hypertension·H IkedaT Imaizumi
Sep 9, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·J P Cooke
Feb 24, 2001·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·E Eleuteri
Sep 13, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Atsushi KatohTsutomu Imaizumi
Dec 6, 2002·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliPietro Finocchiaro
Dec 11, 2003·Atherosclerosis. Supplements·Rainer H Böger, Carmine Zoccali

❮ Previous
Next ❯

Citations

Nov 9, 2012·Journal of Endocrinological Investigation·W XiaY Chi
May 16, 2014·Life Sciences·Koichiro TanahashiSeiji Maeda
Apr 18, 2014·International Journal of Molecular Sciences·Graziano RiccioniTonino Bucciarelli
Aug 1, 2009·Stroke; a Journal of Cerebral Circulation·Aleksandra PikulaSudha Seshadri
Feb 28, 2013·International Journal of Molecular Sciences·Shufen ChenHans Worthmann
Jan 16, 2010·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Noboru Toda, Kazuhide Ayajiki
Dec 6, 2012·International Urology and Nephrology·Aysegul Kudu CobanogluErcan Ok
Jan 22, 2009·European Journal of Clinical Pharmacology·Mei-Fang ChenXiu-Mei Xie
Jul 11, 2009·Climacteric : the Journal of the International Menopause Society·S KilicS Batioglu
Dec 17, 2014·Clinical and Experimental Hypertension : CHE·Wei XiaYingjie Yao
Mar 23, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S EngeliJ Jordan
Jul 29, 2010·Clinical Physiology and Functional Imaging·L Vladimirova-KitovaB Marinov
May 21, 2015·World Journal of Experimental Medicine·Hiroyuki KonyaMitsuyoshi Namba
Jun 22, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M M TanashyanA A Raskurazhev
Apr 20, 2016·Journal of the American Heart Association·Chiao-Po HsuTzong-Shyuan Lee
Oct 12, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Adrian DoroszkoAndrzej Szuba
Jul 1, 2014·Psychosomatic Medicine·Alexander RawRobert W Powers
Mar 11, 2020·International Journal of Molecular Sciences·Gerrit M GrosseChi-Un Choe
Aug 7, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Sanghoon ShinYangsoo Jang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.