PMID: 7371366May 1, 1980Paper

Plasma levels and urinary excretion of vidarabine after repeated dosing

Clinical Pharmacology and Therapeutics
R A BuchananR J Whitley

Abstract

Vidarabine (Vira-A) was given intravenously for 5 days to 5 immunosuppressed patients with herpes zoster. The daily dose, 10 mg/kg, was given by slow infusion over 12 hr. Blood samples were taken at 0, 1, 2, 4, 8, and 12 hr on days 1, 3, and 5. Twenty-four-hour urine specimens were collected before treatment and on days 1, 3, and 5. Blood and urine specimens were assayed for vidarabine and its principal metabolite, hypoxanthine arabinoside (ara-Hx), by high pressure liquid chromatography. The results showed that vidarabine is quickly deaminated; virtually all of the drug present in the plasma and urine was in the form of ara-Hx. The highest plasma level, approximately 3 microgram/ml, was at the end of the infusion period. The urinary excretion of ara-Hx accounted for between 40% and 50% of the dose. The renal clearance values varied, but were close to the expected glomerular filtration rate of 125 ml/min. The plasma levels and the excretion levels were much the same on days 1, 3, and 5, indicating that drug did not cumulate. The results of the study were consistent with those observed in single-dose studies. The results indicated that the infusion of vidarabine is clinically appropriate, since therapeutic plasma levels are reac...Continue Reading

Citations

Apr 26, 1991·Pharmaceutisch Weekblad. Scientific Edition·E H Wiltink, R Janknegt
Jan 1, 1992·Fundamental & Clinical Pharmacology·F FauvelleO Petitjean
Aug 1, 1991·Biopharmaceutics & Drug Disposition·F FauvelleL Guillevin
Nov 13, 2004·Antiviral Chemistry & Chemotherapy·Kunikazu KurosakiKimiyasu Shiraki
Nov 1, 1980·Antimicrobial Agents and Chemotherapy·R J WhitleyR A Buchanan
Sep 1, 1984·Lancet·K G Nicholson
Jul 1, 1992·Survey of Ophthalmology·S A TeichA H Friedman

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